Education on the Role of Prophylactic Ondansetron in Preventing Spinal Anesthesia-Induced Hypotension Among Cesarean Section Patients
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Olivia Lanier (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
- Advisor
- Vadim Korogoda
Abstract: Background: Hypotension resulting from the placement of a spinal anesthetic results in as much as 80% of obstetric patients experiencing low blood pressure over the course of a cesarean section. Hypotension can result in significant side effects for both mother and baby including nausea and vomiting, cardiac collapse, impaired uteroplacental perfusion, and fetal acidosis. Ondansetron is a 5-HT3 receptor antagonist that is effective in attenuating spinal-induced hypotension by blocking serotonin-activated 5-HT3 receptors and preventing the activation of the Bezold-Jarisch reflex, which results in hypotension, bradycardia, and vasodilation. Purpose: This project aimed to evaluate if an educational intervention would result in practice change, increased utilization of prophylactic ondansetron prior to cesarean sections done under spinal anesthesia, and improved patient outcomes. Methods: Participants attended an educational presentation on the role of ondansetron in preventing spinal-induced hypotension (SIH). Pre and post-intervention surveying was used to assess participant knowledge and perceptions on the incidence of clinical outcomes such as hypotension and use of vasopressors. A chart review collected data on elective cesarean sections under spinal anesthesia to evaluate the rate of prophylactic ondansetron use and vasopressor consumption. Results: 52 cases were reviewed, which showed an increase in prophylactic ondansetron administration after the intervention. There was a significant decrease in the average vasopressor consumption after the intervention. However, there was not a relationship between receiving prophylactic ondansetron and the incidence of hypotension. Survey results indicated increased participant knowledge regarding prophylactic ondansetron. Conclusion: The project was successful in resulting in CRNA practice change and increased use of prophylactic ondansetron. Educational presentations are an effective way to inform CRNAs on evidence-based practice recommendations and can result in meaningful practice change and increased knowledge among participants.
Education on the Role of Prophylactic Ondansetron in Preventing Spinal Anesthesia-Induced Hypotension Among Cesarean Section Patients
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Created on 6/27/2024
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Additional Information
- Publication
- Other
- Language: English
- Date: 2024
- Keywords
- ondansetron, hypotension, spinal anesthesia, spinal, spinal-induced, obstetrics, cesarean section