| a-Pyrone Derivatives, Tetra/Hexahydroxanthones, and Cyclodepsipeptides from Two Freshwater Fungi |
2017 |
1379 |
Eighteen (1–18) and seven (1, 4, 6–8, 17 and 18) compounds were isolated from organic extracts of axenic cultures of two freshwater fungi Clohesyomyces sp. and Clohesyomyces aquaticus (Dothideomycetes, Ascomycota), respectively. Compounds 1–12 belong... |
| Bioactive Withanolides from Withania obtusifolia |
2014 |
1633 |
Seven withanolides were isolated from the leaves of Withania obtusifolia. Of these, one was new [obtusifonolide (1)], five were new to the species [sitoindoside IX (2), 6a-chloro-5ß-hydroxy withaferin A (3), isowithanone (4), 2,3-dihydro-3-ethoxywith... |
| Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris |
2015 |
787 |
Sixteen polyketides belonging to diverse structural classes, including monomeric/dimeric tetrahydroxanthones and resorcylic acid lactones, were isolated from an organic extract of a fungal culture Setophoma terrestris (MSX45109) by bioactivity-direct... |
| Chemoinformatic Expedition of the Chemical Space of Fungal Products |
2016 |
596 |
Aim: Fungi are valuable resources for bioactive secondary metabolites. However, the chemical space of fungal secondary metabolites has been studied only on a limited basis. Herein, we report a comprehensive chemoinformatic analysis of a unique set of... |
| Cytotoxic Homoisoflavonoids from the Bulbs of Bellevalia flexuosa |
2018 |
1008 |
Four new homoisoflavonoids, 7-O-methyl-8-demethoxy-3'-hydroxy-3,9-dihydropunctatin (4), 6-hydroxy-8-demethoxy-4'-O-methyl-3,9-dihydropunctatin (8), 7,4'-O-dimethyl-8-demethoxy-3,3'-dihydroxy-3,9-dihydropunctatin (13), and 7-O-methyl-3-hyroxy-3,9-dihy... |
| Discovering new structural diversity from unexplored fungi |
2014 |
3811 |
Discovery of anticancer drugs with high efficacy coupled with action at novel target sites is necessary to combat cancer. As part of a multidisciplinary project to identify anticancer leads from diverse natural product resources, our group has been s... |
| Enhanced Dereplication of Fungal Cultures Via Use of Mass Defect Filtering |
2017 |
1212 |
Effective and rapid dereplication is a hallmark of present-day drug discovery from natural sources. This project strove to both decrease the time and expand the structural diversity associated with dereplication methodologies. A 5?min liquid chromato... |
| Graviola Inhibits Hypoxia-Induced NADPH Oxidase Activity in Prostate Cancer Cells Reducing Their Proliferation and Clonogenicity |
2016 |
442 |
Prostate cancer (PCa) is the leading malignancy among men. Importantly, this disease is mostly diagnosed at early stages offering a unique chemoprevention opportunity. Therefore, there is an urgent need to identify and target signaling molecules with... |
| Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines |
2018 |
785 |
Therapeutic agents used in the treatment of cancer are known to develop resistance against cancer cells. Hence, there is a continuing need to investigate novel agents for the treatment and management of cancer. Antitumor activity of greensporone C (G... |
| In Situ Analysis of Asimina triloba (Paw Paw) Plant Tissues for Acetogenins via the Droplet-Liquid Microjunction-Surface Sampling Probe Coupled to UHPLC-PDA-HRMS/MS |
2016 |
1483 |
Asimina triloba, commonly known as paw paw, is one of approximately 2100 species in the Annonaceae family, scores of which are known to biosynthesize bioactive secondary metabolites, termed Annonaceous acetogenins. Even with over 400 acetogenins iden... |
| Isolation, Semisynthesis, Covalent Docking and Transforming Growth Factor Beta-Activated Kinase 1 (TAK1)-Inhibitory Activities of (5Z)-7-Oxozeaenol Analogues |
2015 |
1470 |
(5Z)-7-Oxozeanol and related analogues were isolated and screened to explore their activity as TAK1 inhibitors. Seven analogues were synthesized and more than a score of natural products isolated that examined the role that different areas of the mol... |
| Mass Spectrometry Imaging of Secondary Metabolites Directly on Fungal Cultures |
2014 |
1457 |
Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient ionization technique that enables imaging experiments directly on fungal cultures. Much information can be gained by examining an organism directly from culture, rather than... |
| Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression |
2019 |
1277 |
Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp. (strain MSX50044); these compounds are similar to the bis-trop... |
| Optimizing Production and Evaluating Biosynthesis in Situ of a Herbicidal Compound, Mevalocidin, from Coniolariella Sp. |
2016 |
1578 |
Mevalocidin is a fungal secondary metabolite produced by Coniolariella sp. It is a unique phytotoxin that demonstrates broad spectrum post-emergent herbicidal properties. With limited options for weed control, the commercialization of a natural produ... |
| Safety Assessment of Mushrooms in Dietary Supplements by Combining Analytical Data with in Silico Toxicology Evaluation |
2017 |
1314 |
Despite growing popularity in dietary supplements, many medicinal mushrooms have not been evaluated for their safe human consumption using modern techniques. The multifaceted approach described here relies on five key principles to evaluate the safet... |
| Scaffold Diversity of Fungal Metabolites |
2017 |
483 |
Many drug discovery projects rely on commercial compounds to discover active leads. However, current commercial libraries, with mostly synthetic compounds, access a small fraction of the possible chemical diversity. Natural products, in contrast, pos... |
| Sorbicillinoid Analogs with Cytotoxic and Selective Anti-Aspergillus Activities from Scytalidium album |
2014 |
1209 |
As part of an ongoing project to explore filamentous fungi for anticancer and antibiotic leads, 11 compounds were isolated and identified from an organic extract of the fungus Scytalidium album (MSX51631) using bioactivity-directed fractionation agai... |