Some Sex Hormone Profiles are Consistent over Time in Normal Menstruating Women: Implications for Sports Injury Epidemiology

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Beverly Levine (Creator)
Sandra J. Shultz, Professor and Chair (Creator)
Laurie Wideman, Safrit-Ennis Distinguished Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Purpose-It is unclear whether sex hormone profiles obtained in two consecutive months are consistent within women. Month-to-month consistency in daily, nadir, peak and mean hormone concentrations during the early follicular and luteal phases in recreationally active, young eumenorrheic women was prospectively examined. Methods-60 healthy, non-smoking women who reported normal and consistent menstrual cycles lasting 26–32 days for the past 6 months were followed prospectively to obtain serum samples for the first 6 days of menses and for 8 days after a positive ovulation test over two consecutive months. Month-to-month consistency of daily concentrations of oestradiol (pg/ml), progesterone (ng/ml), testosterone (ng/dl), sex hormone-binding globulin (nmol/l) and free androgen index were determined using linear mixed models. Month-to-month consistency in nadir, peak and mean concentrations were then assessed using intraclass correlation coefficients and SEM to more precisely examine intraindividual consistency. Results-Linear mixed models revealed stable hormone concentrations across cycles and cycles by day. Reliability estimates for nadir, peak, mean menses and mean postovulatory concentrations range from 0.56 to 0.86 for oestradiol, 0.44 to 0.91 for progesterone, 0.60 to 0.86 for testosterone, 0.88 to 0.97 for sex hormone-binding globulin and 0.78 to 0.91 for free androgen index. Conclusions-Hormone profiles were reproducible over two consecutive months. To reduce month-to-month intraindividual variations and improve measurement consistency, it is recommended that multiple samples be taken over consecutive days as opposed to a single sample.

Additional Information

British Journal of Sports Medicine, 45(9), 735-742
Language: English
Date: 2011
reliability, measurement accuracy, ACL injury, menstrual cycle phase, sex hormones

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