The role of naringenin on ERRa and adipocyte metabolism

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Alma Rosa Chanelo (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:
Yashomati Patel

Abstract: Obesity is a metabolic disorder that is characterized by an increase in adipocyte number and size. The increase in lipid accumulation is due to an increase in glucose uptake and an imbalance between lipogenesis and lipolysis. Many factors regulate lipogenesis and lipolysis to coordinate lipid metabolism. The estrogen related receptor alpha (ERRa) and naringenin have been identified as potent regulators of glucose and lipid metabolism. To determine if naringenin affects lipid accumulation, adipocytes were treated with naringenin for 1, 4, or 16 days, and stained with Oil Red O and lipid droplet size was quantified. Our studies reveal that naringenin decreases the number of large lipid droplets, resulting in a decrease in lipid accumulation overtime. We also observed that naringenin does not have cytotoxic effects on adipocytes. To determine the mechanism by which lipid accumulation decreased we measured the metabolic pathways involved in glucose and lipid metabolism. Our results show a 7.8 fold increase in lactate levels and no effect on acetyl-CoA carboxylase levels, indicating naringenin may cause an increase in the use of glucose for the production of lactate. Finally, we show that the levels of ERRa, a potential binding partner of naringenin and regulator of LDH were elevated in the presence of naringenin. Our findings suggest naringenin may regulate ERRa and thus regulate both glucose and lipid metabolism by funneling glucose towards the production of lactate and away from lipid production. Making naringenin a potentially effective treatment option for obesity. [This abstract has been edited to remove characters that will not display in this system. Please see the PDF for the full abstract.]

Additional Information

Language: English
Date: 2019
Adipocyte metabolism, Naringenin, Obesity
Fat cells
Estrogen $x Receptors
Lipids $x Metabolism

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