Cellular Uptake of Carbon Nanodots in THP-1 Human Monocytes

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Claire Griffith (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/
Zhenquan Jia

Abstract: Cardiovascular disease (CVD) is the leading cause of death worldwide. Many types of treatment options are currently available but include side effects that inhibit quality living for many people. Carbon nanodots are novel carbon nanoparticles with sizes below 10 nanometers and have appeared in the world of nanoparticles over the past decade. Their many features which include green synthesis methods, good biocompatibility, unique luminescence properties, and particularly their low toxicity have made them an attractive option in biomedical research approaches. In biomedical research, it is important to examine the effects of carbon nanodots on cellular uptake to determine the safety of these nanoparticles for further treatments in vivo and in vitro. In this study, we researched the cellular uptake of carbon nanodots in THP-1 human monocytes using Bio-Tek synergy fluorimeter. The results showed a dose-dependent increase in cellular internalization of carbon nanodots after thesethe dose- and time- dependent treatments in THP-1 cells. Our results may help guide further research studies on the potential biomedical application of carbon nanodots in the treatment of cardiovascular diseases.

Additional Information

Honors Project
Language: English
Date: 2019
carbon nanodots, cardiovascular disease, THP-1, monocytes, biomedical

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