Colchicinoids from Colchicum Crocifolium Boiss. (Colchicaceae)

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Nicholas Oberlies, Patricia A. Sullivan Distinguished Professor of Chemistry (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:

Abstract: A new colchicinoid from Colchicum crocifolium Boiss. (Colchicaceae) was isolated and identified as N,N-dimethyl-N-deacetyl-(-)-cornigerine (5), along with four known compounds, but new to the species: (-)-colchicine (1), (-)-demecolcine (2), (-)-N-methyl-(-)-demecolcine (3) and 3-demethyl-N-methyl-(-)-demecolcine (4). All isolated compounds showed potent cytotoxicity against a human cancer cell panel.

Additional Information

Natural Product Research, 24:2, 152-159. PMID:20077308; DOI: 10.1080/14786410902941097
Language: English
Date: 2010
Colchicum crocifolium, colchicinoids, Jordan medicinal plants, colchicine

Email this document to