High performance liquid chromatography/electrospray ionization mass spectrometry for simultaneous analysis of alkamides and caffeic acid derivatives from Echinacea purpurea extracts

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Nadja B. Cech, Patricia A. Sullivan Distinguished Professor of Chemistry (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: Extracts of the plant Echinacea purpurea are widely used for medicinal purposes. Effective quality control of these extracts requires rapid methods to determine their chemical composition. A new method for analysis of caffeic acid derivatives and alkamides from Echinacea extracts has been developed. With this method, isomeric isobutylamides and 2-methylbutylamides can be distinguished, a capability that previously published methods have lacked. Quantitative analyses carried out with this method on E. purpurea extracts that have been stored for 18 months indicate that they contain caftaric acid, cichoric acid, and undeca-2Z,4E-diene-8,10-diynoic acid isobutylamide at concentrations of 0.7, 0.71 and 2.0 mg/mL, respectively.

Additional Information

Journal of Chromatography A, 1103(2), 219-228
Language: English
Date: 2006
Echinacea purpurea, Phenolics, Alkamides, Alkylamides, Isobutylamides, Caffeic acid derivatives, Cichoric acid, Caftaric acid, Dodeca-2E,4E,8Z,10Z-tetraenoic acid, HPLC, Electrospray ionization mass spectrometry, ESI-MS, Quadrupole ion trap

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