Agenesis of the corpus callosum and voluntary wheel running in mice.

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Douglas Wahlsten, Visiting Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Humans born without a corpus callosum (CC) are often comparatively slow and clumsy on tasks requiring bilateral motor coordination. In this study, we attempted to identify correlates of CC agenesis in mice by examining an ecologically valid motor behavior: running-wheel performance. Mice with varying degrees of congenital CC deficits were tested on a running wheel apparatus for 7 consecutive days. The mice became more proficient at running with experience (i.e., rotations, time spent running, length of running bouts, and maximum and modal running speeds increased while variability of rotation times decreased). Multiple regression analysis suggested that CC deficiency may be related to 2 out of 20 measurements of running (decreased variability of rotation times and shorter maximum running bout duration), but at levels below the traditional criteria for significance. Although these variables predicted CC deficiency at a level significantly greater than chance (71% correct) in a discriminant analysis, examination of the meaning of their relationship with CC size suggested that any connection may be spurious.

Additional Information

Psychobiology, 1996, 24, 187-194.
Language: English
Date: 1996
Corpus callosum, Deficiency, Motor skills, Coordination, Mice, Humans

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