Freshwater Fungi as a Source of Chemical Diversity: A Review

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Rick L. Bunch, Professor and Director of Center for GIScience (Creator)
Mario Figueroa Saldivar, Adjunct Faculty (Creator)
Nicholas Oberlies, Patricia A. Sullivan Distinguished Professor of Chemistry (Creator)
Huzefa A. Raja, Postdoctoral Fellow (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: As their name indicates, freshwater fungi occur on submerged substrates in fresh water habitats. This review brings together the chemical diversity and biological activity of 199 of the 280 known freshwater fungal metabolites published from 1992 to 2020, representing at least seven structural classes, including polyketides, phenylpropanoids, terpenoids, meroterpenoids, alkaloids, polypeptides, and monosaccharides. In addition to describing what they are, where they are found, and what they do, we also discuss strategies for the collection, isolation, and identification of fungi from freshwater habitats, with the goal of enhancing chemists’ knowledge of several mycological principles. We anticipate that this review will provide a springboard for future natural products studies from this fascinating but underexplored group of Ascomycota.

Additional Information

Publication
Journal of Natural Products. 2021, 84, 3, 898–916. https://doi.org/10.1021/acs.jnatprod.0c01340
Language: English
Date: 2021
Keywords
fungi, natural products, pharmaceuticals, fresh water, metabolism

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