GPCRs Moonlighting as Scramblases: Mechanism Revealed

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Patricia H. Reggio, Professor and Department Head (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Phospholipids can undergo transverse diffusion, changing leaflets in the bilayer via translocase or scramblase activity. In this issue of Structure, Morra et al. (2018) provide insight into the mechanism used by one scramblase, opsin, based on large-scale ensemble atomistic molecular dynamics simulations. Results support a proposed “credit card reader” model.

Additional Information

Structure 26(2): 184-186
Language: English
Date: 2018
scramblase, GPCR, phospholipid

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