Study Examining Fullerene Toxicity Raises Questions as to the Purity of the Nanomaterials and Erroneous Experimental Conclusions

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Anthony Dellinger (Creator)
Christopher Kepley, Associate Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: To the Editor, We are compelled to comment on a recent article in your journal “C60 Exposure Augments Cardiac Ischemia/Reperfusion Injury and Coronary Artery Contraction in Sprague Dawley Rats; 138(2), 365–378” by Thompson1 in which various conclusions were made concerning the toxicity of C60. In this study, insoluble C60 was mixed with polyvinylpyrrolidone (PVP) and used to challenge rats which were then surgically induced to examine various cardiovascular toxicity parameters. Both intravenously (IV) and intratracheally (IT) exposure to the C60-PVP mixture resulted in expansion of myocardial infarction in male and female rats following I/R injury, elevated inflammatory cytokines, and augmented vasocontraction of coronary arteries.

Additional Information

Toxicological Sciences, 2014 Oct;141(2):326-7.
Language: English
Date: 2014
letter to the editor, fullerenes, toxicity, nanomaterials

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