Syk deficiency in human non-releaser lung mast cells

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Christopher Kepley, Associate Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Human lung mast cells, like peripheral blood basophils, can have a non-releaser phenotype characterized by a failure to respond to FceRI-IgE-mediated stimulation [1]. Previous studies on human basophils demonstrated that approximately 10–15% of donors fail to release histamine in response to FceRI crosslinking [2], [3], [4], [5] and that depressed protein levels of the tyrosine kinase Syk correlated with this non-releaser status [6], [7]. Here we present evidence for diminished Syk protein in a second preparation of lung mast cells with a non-releasing phenotype.

Additional Information

Clinical Immunology 2007; 125(1):112-5.
Language: English
Date: 2007
letter to the editor, lung mast cells, non-releaser phenotype, Syk, IgE

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