The Annonaceous Acetogenin Bullatacin Is Cytotoxic against Multidrug Resistant Human Mammary Adenocarcinoma Cells

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Nicholas Oberlies, Patricia A. Sullivan Distinguished Professor of Chemistry (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:

Abstract: Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.

Additional Information

Cancer Letters, 115, 73-79. PMID: 9097981; doi: 10.1016/S0304-3835(97)04716-2
Language: English
Date: 1997
Acetogenins, Bullatacin, Multidrug resistance, P-gp, Mammary adenocarcinoma

Email this document to