Fullerenes and their potential in nanomedicine

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Anthony Dellinger (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/
Christopher Kepley

Abstract: Carboxyfullerenes are closed carbon spheres which are being actively pursued globally for a wide range of applications. Their inherent properties and ability to be functionalized with side-chains results in nearly limitless new chemical structures making them ideal platform molecules for new solutions to basic biological problems. In general, two classes of fullerenes exist for nanomedicine applications; empty cage and metallo-fullerenes. The carbon cage (usually C60 and C70) of empty cage fullerenes are anti-oxidants, thus potential therapeutics for inflammatory diseases. Our discovery that certain fullerene derivatives can stabilize and prevent pro-inflammatory mediator release from human tissue mast cells make them ideal candidates for diseases controlled by MC mediators (e.g. arthritis, asthma, etc.). New research findings using metallo-fullerenes with gadolinium inside the carbon cage as diagnostics using Magnetic Resonance Imaging for inflammatory diseases suggest metallo-fullerenes are more sensitive than current contrast agents, have the ability to be targeted to disease specific biomarkers, and are safe.

Additional Information

Language: English
Date: 2015
Arthritis, Atherosclerosis, Fullerenes, Inflammation, Mast Cells
Fullerenes $x Therapeutic use

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