Zhenquan Jia

Education: Ph.D. in Toxicology/Biomedical & Veterinary Sciences; Virginia Polytechnic Institute and State University (Virginia Tech), 2006; Postdoctoral Fellow, Edward Via College of Osteopathic Medicine, Virginia Tech Corporate Research Center, 2007-2008; Assistant Professor, Edward Via College of Osteopathic Medicine, Virginia Tech Corporate Research Center, 2009-2011. **Expertise: Biomedical Toxicology.

There are 25 included publications by Zhenquan Jia :

TitleDateViewsBrief Description
Antioxidant capacity of Nitrogen and Sulfur co-doped carbon nanodots 2018 22 Carbon nanodots (CNDs) have shown potential for antioxidative activity at the cellular level. Here we applied a facile hydrothermal method to prepare fluorescent nitrogen and sulfur (N,S-) codoped CNDs using a-lipoic acid, citric acid, and urea as pr...
Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial Dysfunction 2018 20 Scope: Lipotoxicity-induced endothelial dysfunction is an important vascular complication associated with diabetes. Clinical studies support the vascular benefits of blueberry anthocyanins, but the underlying mechanism is unclear. The hypothesis that...
A Brief Review of Biomarkers for Preventing and Treating Cardiovascular Diseases 2012 1087 Cardiovascular diseases are the most prominent circulation disorders around the world. Biomarkers are characteristic biological properties that can be objectively measured as an indicator to evaluate a variety of health or disease characteristics. Ca...
Carbon nanodots interference with lactate dehydrogenase assay in human monocyte THP-1 cells 2014 1443 Background: Carbon nanodots (CD), a new class of carbon nanomaterials with sizes below 10 nm, have recently attracted wide attention due to their superiority in water solubility, chemical inertness, and resistance to photobleaching. As a result, CD h...
Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling 2018 39 Atmospheric pollution has been a principal topic recently in the scientific and political community due to its role and impact on human and ecological health. 9,10-phenanthrenequinone (9,10-PQ) is a quinone molecule found in air pollution abundantly ...
Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice 2019 22 Gut microbiota contributes to the biological activities of berry anthocyanins by transforming them into bioactive metabolites, and anthocyanins support the growth of specific bacteria, indicating a two-way relationship between anthocyanins and microb...
Effects of chain length of saturated fatty acids on Aß generation in SH-SY5Y cells 2019 19 Many studies have shown that saturated fat diet increases the risk of AD. Recently saturated very long chain fatty acids (VLCFAs) have been found be accumulated in AD patients. The variety of saturated fatty acids are found in the diets and human bod...
EPR studies on hydroxyl radical-scavenging activities of pravastatin and fluvastatin 2012 1345 Statins are known clinically by their cholesterol reduction properties through the inhibition of HMG-CoA reductase. There is mounting evidence suggesting a protective role of statins in certain types of cancer, cardiac, and vascular disease through a...
Genistein Induces Pancreatic ß-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice 2010 1224 Genistein, a flavonoid in legumes and some herbal medicines, has various biological actions. However, studies on whether genistein has an effect on pancreatic ß-cell function are very limited. In the present study, we investigated the effect of genis...
The Highly Expressed and Inducible Endogenous NAD(P)H:quinone Oxidoreductase 1 in Cardiovascular Cells Acts as a Potential Superoxide Scavenger 2007 981 It has recently been demonstrated that purified NAD(P)H:quinone oxidoreductase 1 (NQO1) is able to scavenge superoxide (O 2 •- ) though the rate of reaction of O 2 •- with NQO1 is much lower than the rate of enzymatic dismutation catalyzed by superox...
Induction of oxidative DNA damage by mesalamine in the presence of copper: A potential mechanism for mesalamine anticancer activity 2011 1176 Mesalamine is the first line pharmacologic intervention for patients with ulcerative colitis, and recent epidemiologic studies have demonstrated a protective association between therapeutic use of the drug and colorectal carcinoma. However, the mecha...
Leptin’s Activity on the Hydroxyl Radical: A Possible Link to the Oxidative Stress-Related Endothelial Vasodilation in Patients with Obstructive Sleep Apnea 2013 672 Purpose: Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity, whereas the underlying mechanism is still eluding, the thought participants are chronic intermittent hypoxia with consequent increase in the reactive oxygen...
Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent 2014 2182 Beta-lapachone (beta-Lp) derived from the Lapacho tree is a potentially novel anticancer agent currently under clinical trials. Previous studies suggested that redox activation of beta-Lp catalyzed by NAD(P)H:quinone oxidoreductase 1 (NQO1) accounted...
Microbiome modulates intestinal homeostasis against inflammatory diseases 2018 54 Eliminating prophylactic antibiotics in food animal production has exerted pressure on discovering antimicrobial alternatives (e.g. microbiome) to reduce elevated intestinal diseases. Intestinal tract is a complex ecosystem coupling host cells with m...
Nanospray desorption electrospray ionization mass spectrometry of untreated and treated probiotic Lactobacillus reuteri cells 2018 17 Mass spectrometry has proven to be a useful technique for rapid identification of bacterial cells. Among various ionization techniques in mass spectrometry, matrix-assisted laser desorption/ionization (MALDI) has been commonly used for the identifica...
Natural Products Targeting on Oxidative Stress and Inflammation: Mechanisms, Therapies, and Safety Assessment 2018 35 Substantial evidence suggests that overproduction of reactive oxygen species (ROS) and its associated oxidative stress and inflammatory responses play a crucial role in the pathogenesis of various human chronic diseases including diabetes, cardiovasc...
Nuclear Factor E2-Related Factor 2-Dependent Myocardiac Cytoprotection Against Oxidative and Electrophilic Stress 2008 1157 Nuclear factor E2-related factor 2 (Nrf2) is a critical regulator of cytoprotective gene expression. However, the role of this transcription factor in myocardiac cytoprotection against oxidative and electrophilic stress remains unknown. This study wa...
Oxidative stress in spinal cord injury and antioxidant-based intervention 2012 1546 Study design: Literature review.Objectives: Spinal cord injury (SCI) remains a major public health issue in developed countries as well as worldwide. The pathophysiology of SCI is characterized by an initial primary injury followed by secondary deter...
Phytoestrogen Genistein Protects Against Endothelial Barrier Dysfunction in Vascular Endothelial Cells Through PKA-Mediated Suppression of RhoA Signaling 2013 848 The soy-derived phytoestrogen genistein has received attention for its potential to improve vascular function, but its mechanism remains unclear. Here, we report that genistein at physiologically relevant concentrations (0.1–10 µM) significantly inhi...
Phytonutrient genistein is a survival factor for pancreatic ß-cells via GPR30-mediated mechanism 2018 16 We previously discovered that phytonutrient genistein rapidly activates cAMP signaling in ß-cells and improves islet mass in diabetic mice. However, the mechanism underlying these actions of genistein is still unclear. Here, we show that pharmacologi...
Protection against peroxynitrite-induced DNA damage by mesalamine: implications for anti-inflammation and anti-cancer activity 2013 1020 Mesalamine (5-aminosalicylic acid, 5-ASA) is known to be the first-line medication for treatment of patients with ulcerative colitis. Studies have demonstrated that ulcerative colitis patients treated with 5-ASA have an overall decrease in the risk o...
Reactive oxygen species in in vitro pesticide-induced neuronal cell (SH-SY5Y) cytotoxicity: Role of NF?B and caspase-3 2007 1528 Oxidative stress has been implicated in pesticide-induced neurotoxicity, based on its role in the cascade of biochemical changes that lead to dopaminergic neuronal cell death. We have, therefore, examined the role of oxidative stress caused by the pe...
A recent review of citrus flavanone naringenin on metabolic diseases and its potential sources for high yield-production 2018 17 Background: Metabolic syndromes are the multi-metabolic abnormality characterized by hyperlipidemia, obesity, hyperglycemia, diabetes, hypertension, cardiovascular disease, and neuro-dysfunction. Naringenin, a naturally occurring flavanone compound, ...
Role of leptin as antioxidant in obstructive sleep apnea: an in vitro study using electron paramagnetic resonance method 2013 1005 Introduction: As in obstructive sleep apnea (OSA), the chronic cycles of hypoxia and reoxygenation are thought to be conducive of oxidative stress (OS) with generation of reactive oxygen species, identifying effective mechanisms of protection against...
Systematic evaluation of polyphenols composition and antioxidant activity of mulberry cultivars subjected to gastrointestinal digestion and gut microbiota fermentation 2018 9 In this study, mulberry cultivars were found to have abundant bioactive compounds such as phenolics (100.97–586.23?mg gallic acid equivalents/100?g fresh weight), flavonoids (16.38–368.16?mg rutin equivalents/100?g fresh weight) and procyanidins (4.2...