Joseph M. Starobin

Prof. Starobin's professional career has been devoted to the application of methods of theoretical, mathematical and computational physics to cardiovascular research. In collaboration with his colleagues at MIT and Naval Research Laboratory he has developed an exactly solvable reaction-diffusion model. The Chernyak-Starobin-Cohen model allows one to determine analytically the stable steady-state wave-train solutions and to compute basic cycle length curves that describe the underlying properties of wave propagation in excitable media. A major product of his earlier research was the development and implementation of the theoretical analysis of reaction-diffusion media for predicting cardiac ischemia and malignant cardiac arrhythmias under conditions of quasi-stationary exercise. The emphasis of Prof. Starobin’s current research is on improving the quality of electrophysiological data collection with MEMS and nano-enabled sensors. This work along with the extensive mathematical modeling of the dynamics of non-linear waves will eventually result in clinical implementation of the methods that he has developed so far using smaller, smarter and less costly electrophysiological devices.

There are 6 included publications by Joseph M. Starobin :

TitleDateViewsBrief Description
Action potential restitution and hysteresis in a reaction-diffusion system with pacing rate dependent excitation threshold 2008 832 We have demonstrated that rate dependent restitution and action potential duration-refractory period hysteresis can be reproduced in a one-dimensional two-variable Chernyak-Starobin-Cohen reaction-diffusion medium with variable excitation threshold. ...
Assessing QT-RR interval hysteresis in 12-lead electrocardiograms 2009 716 The amount of QT-RR interval hysteresis accumulated during the load and recovery phases of exercise stress test reflects the degree of exercise induced myocardial ischemia. Therefore the evaluation of hysteresis from 12-lead ECG (12-SL) is an importa...
Critical scale of propagation influences dynamics of waves in a model of excitable medium 2009 791 Background: Duration and speed of propagation of the pulse are essential factors for stability of excitation waves. We explore the propagation of excitation waves resulting from periodic stimulation of an excitable cable to determine the minimal stab...
Entrainment of marginally stable excitation waves by spatially extended sub-threshold periodic forcing 2011 665 We introduce a novel approach of stabilizing the dynamics of excitation waves by spatially extended sub-threshold periodic forcing. Entrainment of unstable primary waves has been studied numerically for different amplitudes and frequencies of additio...
Exercise-induced QT/R-R–interval hysteresis as a predictor of myocardial ischemia 2006 988 Objectives: Exercise-induced QT/RR hysteresis exists when, for a given R-R interval, the QT interval duration is shorter during recovery after exercise than during exercise. We sought to assess the association between QT/RR hysteresis and imaging evi...
Feasibility of non-invasive determination of the stability of propagation reserve in patients 2012 635 This study investigates the feasibility of using surface ECG recordings to assess stability of cardiac propagation. Our novel method customizes a reaction diffusion model of cardiac excitation using measurements of patient’s repolarization dynamics. ...