Laurie Wideman

Laurie Wideman, Ph.D., is the Safrit-Ennis Distinguished Professor in Kinesiology at the University of North Carolina at Greensboro. Laurie earned a BSc. in Biology in 1990 from the University of Waterloo and a Masters degree in Exercise Physiology from Ball State University in 1993. In 1997, she earned a Ph.D. in Exercise Physiology from the University of Virginia. She has served on the faculty at UNCG since 2000. Prior to joining the UNCG faculty, she was a full-time research technician at the NIH funded General Clinical Research Center at the University of Virginia. Professor Wideman teaches in the areas of body composition, endocrine function, exercise physiology, pathophysiology and pharmacology. She has conducted research on the effects of exercise on growth hormone release, the use of physical activity to reduce risk factors for chronic disease, obesity and body composition. Her work has been published in journals such as American Journal of Physiology, Metabolism, Journal of Applied Physiology, Medicine & Science in Sports & Exercise, Diabetes, Journal of Clinical Endocrinology & Metabolism, Geriatric Nursing, and Sports Medicine. Her research has received funding from several local and regional organizations including the Moses Cone~Wesley Long Community Health Foundation, Champion Athleticwear, and North Carolina Institute of Nutrition. Dr. Wideman is a collaborator on the National Institutes of Health (NCMHD) funded grant investigating health disparities in the Triad. She is a member of the Endocrine Society, the American College of Sports Medicine and the Heart & Stroke Health Partnership.

There are 66 included publications by Laurie Wideman :

TitleDateViewsBrief Description
Accuracy of Calendar-Based Methods for Assigning Menstrual Cycle Phase in Women 2013 717 Background: Sex steroid hormone fluctuations during the menstrual cycle are considered a risk factor for noncontact anterior cruciate ligament injuries.Objective: To determine whether self-reported menstrual history data can be used to accurately cat...
Acute exercise-induced growth hormone is attenuated in response to short-term, high intensity exercise training 2014 265 The aim of this study was to determine if 3-wks of short-term, high-intensity exercise training (HIT) alters growth hormone (GH) release. Nineteen recreationally active males (Mean ± SD) (age = 24.9 ± 3.9 yrs, BF% = 20.1 ± 7.7) participated in this s...
Assessment of the Aerosport TEEM 100 portable metabolic measurement system. 1996 2773 The present study evaluated the utility of a portable metabolic measurement system, the Aerosport TEEM 100. A total of 505 data points [242 from incremental (INC) and 263 from constant load (CL) exercise] were collected on 12 subjects (age = 25 ± 4 y...
Attitudes toward physical activity in adolescents with Cystic Fibrosis: Gender differences with exercise training 2006 2736 This study compared the attitudes of 16 adolescents (8 males and 8 females) with cystic fibrosis (CF) toward exercise and physical activity (PA) before and after a 6-week exercise program. Although the boys and girls had similar ages (12–18 years), t...
Body composition by DEXA in older adults: accuracy and influence of scan mode 1997 5 Dual energy x-ray absorptiometry (DEXA) measures bone mineral content(BMC), bone mineral density (BMD), fat-free mass (FFM), and provides estimates of percent body fat. Changes in scan mode geometry (pencil beam vs array) may impact these measures an...
Catecholamine release, growth hormone secretion, and energy expenditure during exercise vs. recovery in men 2000 4 We examined the relationship between energy expenditure (in kcal) and epinephrine (Epi), norepinephrine (NE), and growth hormone (GH) release. Ten men [age, 26 yr; height, 178 cm; weight, 81 kg; O2 uptake at lactate threshold (LT), 36.3 ml · kg-1 · m...
Changes in serum collagen markers, IGF-I, and Knee joint laxity across the menstrual cycle 2012 683 Variations in serum markers of collagen production (CICP) and degradation (ICTP), insulin-like growth factor I (IGF-I) and anterior knee laxity (AKL) were measured in 20 women [10 with spontaneous cycles (eumenorrheic), 10 using oral contraceptives] ...
Childhood temperament predictors of adolescent physical activity 2017 4 Background: Physical inactivity is a leading cause of mortality worldwide. Many patterns of physical activity involvement are established early in life. To date, the role of easily identifiable early-life individual predictors of PA, such as childhoo...
Collagen Gene Variants Previously Associated With Anterior Cruciate Ligament Injury Risk Are Also Associated With Joint Laxity 2012 860 Background: Genetic association studies demonstrate a relationship between several collagen gene variants and anterior cruciate ligament (ACL) injury, yet the mechanism of these relationships is still unclear. Joint laxity is a heritable trait; incre...
Comparison of Estimations Versus Measured Oxygen Consumption at Rest in Patients With Heart Failure and Reduced Ejection Fraction Who Underwent Right-Sided Heart Catheterization 2015 584 Cardiac output during right-sided heart catheterization is an important variable for patient selection of advanced therapies (cardiac transplantation and left ventricular assist device implantation). The Fick method to determine cardiac output is com...
Contrasting negative-feedback control of endogenously driven and exercise-stimulated pulsatile growth hormone secretion in women and men 2004 5 GH represses its own secretion via rapid and reversible feedback exerted at key hypothalamic loci. The primary mechanisms include stimulation of somatostatin release and inhibition of GHRH outflow. Autoinhibition is prominent in the adult male rat bu...
Diets rich in fruits and vegetables are associated with lower cardiovascular disease risk in adolescents 2018 5 Obesity and cardiovascular disease (CVD) risk are public health concerns in adolescents, yet few studies have examined the association of their diet to CVD risk factors. This study investigated associations between diet, body mass index (BMI), waist ...
Early Detection of Type 2 Diabetes Among Older African-Americans 2004 2182 The purpose of this research was to determine whether a group of African Americans who had no diagnosis of type 2 diabetes had elevated blood glucose levels and other risk factors indicative of type 2 diabetes. A convenience sample of 20 African Amer...
The effect of an exercise intervention during early lactation on bone mineral density during the first year postpartum 2019 6 Background: During lactation, women may lose up to 10% of bone mineral density (BMD) at trabecular-rich sites. Previous studies show that resistance exercise may slow BMD; however, the long-term effects of exercise on BMD during lactation have not be...
Effect of Exercise Training on Loss of Bone Mineral Density during Lactation 2009 431 Purpose: During lactation, women transfer approximately 200 mg of calcium per day to breast milk. For 6 months, this is equivalent to 3%–9% of bone mineral density (BMD) loss at trabecular-rich sites. Bone mass usually returns to prepregnancy levels ...
The effect of exercise type on immunofunctional and traditional growth hormone. 2007 1751 The purpose of this study was to compare the growth hormone (GH) response, including the immunfunctional (IF) GH response, between an acute bout of aerobic and resistance exercise in the same subjects. Ten cross-trained males (24.3 ± 1.2 years) perfo...
Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress 2005 12759 The purpose of this study was to compare oxidative modification of blood proteins, lipids, DNA, and glutathione in the 24 hours following aerobic and anaerobic exercise using similar muscle groups. Ten cross-trained men (24.3 ± 3.8 years, [mean ± SEM...
The effects of acute exercise on memory and brain-derived neurotrophic factor (BDNF) 2016 6 Acute exercise benefits cognition, and some evidence suggests that brain-derived neurotrophic factor (BDNF) plays a role in this effect. The purpose of this study was to explore the dose–response relationship between exercise intensity, memory, and B...
Effects of a Dairy Supplement and Resistance Training on Lean Mass and Insulin-Like Growth Factor in Women 2011 351 Purpose: To examine the effect of yogurt supplementation pre- and postexercise on changes in body composition in overweight women engaged in a resistance-training program.Methods: Participants (age = 36.8 ± 4.8 yr) with a body-mass index of 29.1±2.1 ...
The effects of a duathalon simulation on ventilatory threshold and running economy 2016 218 Multisport events continue to grow in popularity among recreational, amateur, and professional athletes around the world. This study aimed to determine the compounding effects of the initial run and cycling legs of an International Triathlon Union (I...
Effects of Energy Restriction and Exercise on Bone Mineral Density during Lactation 2012 428 Modest energy restriction combined with resistance training (RT) has been shown in nonlactating women to protect bone during periods of weight loss. However, there is a paucity of research on dietary interventions and exercise in lactating women aime...
Effects of gender on exercise-induced growth hormone release 1999 5 We examined gender differences in growth hormone (GH) secretion during rest and exercise. Eighteen subjects (9 women and 9 men) were tested on two occasions each [resting condition (R) and exercise condition (Ex)]. Blood was sampled at 10-min interva...
Effects of an Individualized Soccer Match Simulation on Vertical Stiffness and Impedance 2012 856 An observed relationship between soccer match duration and injury has led to research examining the changes in lower extremity mechanics and performance with fatiguing exercise. Because many fatigue protocols are designed to result in substantial mus...
Effects of Tai Chi Chuan on Insulin and Cytokine Levels in a Randomized Controlled Pilot Study on Breast Cancer Survivors 2011 1338 Background-Tai Chi Chuan (TCC) is an integrative medicine mind-body practice with a physical activity component that has positive effects on aerobic capacity, muscular strength, and quality of life among cancer survivors, similar to the effects elici...
Estradiol supplementation selectively relieves growth hormone (GH)'s autonegative feedback on GH-releasing peptide-2 (GHRP-2)-stimulated GH secretion 2001 6 Female gender confers resistance to GH autonegative feedback in the adult rat, thereby suggesting gonadal or estrogenic modulation of autoregulation of the somatotropic axis. Here we test the clinical hypothesis that short-term E2 replacement in ovar...
Exercise and the cortisol awakening response: a systematic review 2017 399 Background: The cortisol awakening response (CAR) has been used as a biomarker of stress response in a multitude of psychological investigations. While a myriad of biochemical responses have been proposed to monitor responses to exercise train...
Exercise-dependent growth hormone release is linked to markers of heightened central adrenergic outflow 2000 4 To test the hypothesis that heightened sympathetic outflow precedes and predicts the magnitude of the growth hormone (GH) response to acute exercise (Ex), we studied 10 men [age 26.1 ± 1.7 (SE) yr] six times in randomly assigned order (control and 5 ...
Exercise-induced growth hormone during acute sleep deprivation 2014 323 The effect of acute (24-h) sleep deprivation on exercise-induced growth hormone (GH) andinsulin-like growth factor-1 (IGF-1) was examined. Ten men (20.6 ± 1.4 years) completed tworandomized 24-h sessions including a brief, high-intensity exercise bou...
Gender governs the relationship between exercise intensity and growth hormone release in young adults 2002 4 We previously reported that in young adult males growth hormone (GH) release is related to exercise intensity in a linear dose-response manner (Pritzlaff et al. J Appl Physiol 87: 498–504, 1999). To investigate the effects of gender and exercise inte...
Gender modulates sequential suppression and recovery of pulsatile GH secretion by physiological feedback signals in young adults 2005 3 The basic mechanisms that drive the renewal of GH pulses in the human are not understood. Recent ensemble models predict that pulse regeneration requires quenching of an ongoing GH pulse by somatostatin outflow and evocation of a new burst by rebound...
Growth hormone (GH) release during acute and chronic aerobic and resistance exercise: Recent Findings. 2002 10942 Exercise is a potent physiological stimulus for growth hormone (GH) secretion, and both aerobic and resistance exercise result in significant, acute increases in GH secretion. Contrary to previous suggestions that exercise-induced GH release requires...
Growth hormone response to graded exercise intensities is attenuated and the gender difference abolished in older adults 2006 4 We investigated the joint impact of age, gender, and exercise intensity on growth hormone (GH) secretion. At a university center, nine young men, eight young women, seven older men, and six older women were each tested on six randomly ordered occasio...
Heart of Hypertension Project: Development of a Community-Based Prevention Program for Young African American Men 2013 184 Background: Early-onset hypertension (HTN) is a major contributor to shortened life expectancy of African American men. Lifestyle changes are known to reduce blood pressure (BP); however, interventions tailored for young African American men have not...
High Intensity Interval Training in Healthy Males Does not Improve Markers of Insulin Sensitivity 2015 158 Purpose: Determine if three weeks of HIT (high-intensity interval training) improves fasting insulin sensitivity in healthy males. Methods: Participants were recreationally active ( = 10 hours per week) men between 18 and 35 years of age (Ht: 180 ± 1...
High-Intensity Exercise and Carbohydrate Supplementation do not Alter Plasma Visfatin 2017 3 The purpose of the study was to examine the effect of high-intensity exercise and carbohydrate supplementation (CHO) on plasma visfatin. On 2 separate days, 10 sprint-trained males (age = 26.4 ± 5.3 yr; Ht = 1.77 ± 0.03 m; Wt = 78.78 ± 9.10 kg; BF% =...
Impact of abdominal visceral fat (VAF), growth hormone (GH), fitness and insulin on lipids and lipoproteins in older adults 2003 2540 We examined the relationship between abdominal visceral fat (AVF) and plasma concentrations of lipids and lipoproteins in 19 females (F) (not on estrogen) and 31 males (M) over the age of 60 (age = 66.8 years). In addition, the effects of growth horm...
Impact of acute exercise intensity on pulsatile growth hormone release in men 1999 4 To investigate the effects of exercise intensity on growth hormone (GH) release, 10 male subjects were tested on 6 randomly ordered occasions [1 control condition (C), 5 exercise conditions (Ex)]. Serum GH concentrations were measured in samples obta...
The impact of sex and exercise duration on growth hormone secretion 2006 4 Previous research clearly indicates a linear relationship between exercise intensity and growth hormone (GH) release and that this relationship is influenced by sex. The present study examined the GH response to increasing exercise duration in young ...
Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene). 2000 1808 Diabetes resulting from heterozygosity for an inacti¬vating mutation of the homeodomain transcription factor insulin promoter factor 1 (IPF-1) is due to a genetic defect of ß-cell function referred to as maturity-onset diabetes of the young 4. IPF-1 ...
The Influence of Anatomical Boundaries, Age, and Sex on the Assessment of Abdominal Visceral Fat 1997 5 Single-slice abdominal computed tomography (CT) scanning has been used extensively for the measurement of abdominal visceral fat (AYF). Optimal anatomical scan location and pixel density ranges have been proposed and are specifically reported to allo...
Influence of Lean Body Mass and Strength on Landing Energetics 2012 942 Purpose: Less lean body mass may limit one’s ability to produce adequate muscle forces to safely control landing from a jump, thus increasing the risk for injury. The primary objective of this study was to determine the effect of lower extremity lean...
Innovative Research Exploring the Effects of Physical Activity and Genetics on Cognitive Performance in Community-Based Older Adults 2015 829 Physical activity is predictive of better cognitive performance and lower risk of Alzheimer’s disease (AD). The apolipoprotein E gene (APOE) is a susceptibility gene for AD with the e4 allele being associated with a greater risk of AD. Cross-sectiona...
Intensity of acute exercise does not affect serum leptin concentrations in young men. 2000 1874 Purpose: We examined the effects of exercise intensity on serum leptin levels. Methods: Seven men (age = 27.0 yr; height = 178.3 cm; weight = 82.2 kg) were tested on a control (C) day and on 5 exercise days (EX). Subjects exercised (30 min) at the f...
Melatonin replacement nullifies the effect of light-induced functional pinealectomy on nociceptive rhythm in the rat 1994 4 Rats maintained on a 12 h daily photoperiod (12:12 LD cycle), exhibited a diunal variation in sensitivity to both heat-elicited and pressure-elicited pain, with low sensitivity at 2 h before the end of the scotophase and higher at 4 h after the onset...
Motivating mature adults to be physically active 2017 6 As a population, middle-aged and older adults are not meeting national guidelines for exercise. The purpose of this study was to describe factors associated with exercise adherence in an 8-month program offered as part of a research study testing the...
Obesity indices are predictive of elevated C-reactive protein in long-haul truck drivers 2016 351 Background: Obesity rates in long-haul truck drivers have been shown to be significantly higher than the general population. We hypothesized that commercial drivers with the highest levels of general obesity and abdominal adiposity would have higher ...
Phosphorylation of the JAK2- STAT5 pathway in response to acute aerobic exercise in young, healthy males. 2008 1719 Growth hormone (GH) is a powerful stimulator of the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) pathway. Acute exercise is a known stimulus for GH secretion. Purpose: The purpose of this study was to determine th...
The Physical Activity and Alzheimer's disease (PAAD) study: Cognitive outcomes 2018 7 Background: Alzheimer’s disease is a progressive disease that degrades cognitive functioning and ultimately results in death. Currently, there is no cure for Alzheimer’s disease and, hence, the identification of preventative strategies is important. ...
Physiological risk profiles and allostatic load: Using latent profile analysis to examine socioeconomic differences in physiological patterns of risk 2019 6 Purpose. The current study sought to expand implications of physiological weathering through the application of latent profile analysis to stress biomarkers to address limitations of traditional allostatic load calculations. Methods. Latent profile a...
Plasma protein carbonyl response to increasing exercise duration in aerobically trained men and women 2007 2772 The purpose of this study was to determine the effect of aerobic exercise duration on plasma protein carbonyl concentrations, a marker of protein oxidation, in aerobically trained men and women. Eight men (age: 27 ± 4 years, V·O2peak: 4.09 ± 0.26 L ·...
Quality of life as a mediator of leisure activity and perceived health among older women 2018 11 Despite consistent evidence to suggest that participating in leisure is associated with perceived health status among older adults, there have been few attempts to determine the possible underlying mechanisms in this relationship, including the role ...
The relationship between exercise-induced and non-stimulated 24-hour growth hormone release 2014 216 The purpose of this study was to quantify the relationship between the acute exercise-induced growth hormone (GH) response, gender, fitness, age, and body composition with non-exercise stimulated (NES) 24-hr integrated GH concentration (IGHC). Twenty...
The Relationship Between Physical Activity and Perceived Health Status in Older Women: Findings from the Woman’s College Alumni Study 2014 845 Using data collected from the Woman’s College (WC) Alumni Study, the purpose of this study was to determine whether perceived health status is related to physical activity in older women. A multiple linear regression analysis was conducted to examine...
Some Sex Hormone Profiles are Consistent over Time in Normal Menstruating Women: Implications for Sports Injury Epidemiology 2011 1409 Purpose-It is unclear whether sex hormone profiles obtained in two consecutive months are consistent within women. Month-to-month consistency in daily, nadir, peak and mean hormone concentrations during the early follicular and luteal phases in recre...
Substrate oxidation is not altered during exercise in cystic fibrosis. 2009 2456 Purpose: To determine substrate utilization and energy expenditure during maximal and submaximal exercise and recovery in adolescents with cystic fibrosis (CF) and healthy age-matched controls (C). Methods: Ten clinically stable CF patients (four gi...
Synergy of L-arginine and growth hormone (GH)-releasing peptide (GHRP-2) stimulation of GH in men and women: Modulation by exercise 2000 5 We investigated the ability of exercise, a multipathway, potent, physiological stimulus for GH release, to alter the synergistic interaction of l-arginine (A) and GH-related peptide (GHRP)-2 (G) observed at rest and the ability of gender to further m...
Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 (GHRP-2) stimulation of GH release: Influence of gender 2000 3 We test the hypotheses that 1) growth hormone (GH)-releasing peptide-2 (G) synergizes with l-arginine (A), a compound putatively achieving selective somatostatin withdrawal and 2) gender modulates this synergy on GH secretion. To these ends, 18 young...
Temperamental vulnerability to emotion dysregulation and risk for mental and physical health challenges 2019 6 Emotion dysregulation characterizes many forms of psychopathology. Patterns of dysregulation occur as a function of a developmental process in which normative and adaptive emotion regulation skills fail to become part of the child's behavioral repert...
Understanding the role of sleep quality and sleep duration in commercial driving safety 2016 44 Introduction: Long-haul truck drivers in the United States suffer disproportionately high injury rates. Sleep is a critical factor in these outcomes, contributing to fatigue and degrading multiple aspects of safety-relevant performance. Both s...
Vagal dysregulation in early childhood and cardiovascular risk in adolescence 2017 3 Objective: Poor behavioral self-regulation in the first 2 decades of life has been identified as an important precursor of disease risk in adulthood. However, physiological regulation has not been well studied as a disease risk factor before adulthoo...
Validity of methods of body composition assessment in young and older men and women 1999 6 We examined the validity of percent body fat (%Fat) estimation by two-compartment (2-Comp) hydrostatic weighing (Siri 2-Comp), 3-Comp dual-energy X-ray absorptiometry (DEXA 3-Comp), 3-Comp hydrostatic weighing corrected for the total body water (Siri...
The validity of regulating blood lactate concentration during running by ratings of perceived exertion 1996 6 We examined whether ratings of perceived exertion (RPE) observed during an incremental (response) protocol could be used to produce target blood [HLa] of 2.5 mM and 4.0 mM during a 30-min treadmill run at a constant RPE. RPE (15.3, 17.6, 19.1), oxyge...
Whole organ transplantation and glucose regulation. 2001 1013 Pancreas transplantation has gained clinical acceptance since its initial application more than 30 years ago. A constellation of surgical, pharmacologic, and metabolic alterations occur with transplantation, particularly if pancreatic transplantation...
Work and chronic disease: Comparison of cardiometabolic risk markers of truck drivers and the general US population 2016 163 Objective: US long-haul truck drivers experience a wide array of excess cardiometabolic disease (CMD) risks unique to their occupation. How these risks translate to, and potentially induce, elevations in the clinical CMD risk profile of this populati...
Work organization, sleep and metabolic syndrome among long-haul truck drivers 2017 92 Background: The work organization of long-haul truck drivers in the USA contains factors that have been shown to degrade sleep. In combination, these factors generate elevated cardiometabolic risk by inducing components of the metabolic syndro...
Work, sleep, and cholesterol levels of U.S. long-haul truck drivers 2017 246 Long-haul truck drivers in the United States experience elevated cardiovascular health risks,possibly due to hypercholesterolemia. The current study has two objectives: 1) to generate acholesterol profile for U.S. long-haul truck drivers; and 2) to d...