Jia, Zhenquan

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There are 14 item/s.

TitleDateViewsBrief Description
Enhancement of endogenous glutathione and NQO1 by triterpenoid CDDO-Im in SH-SY5Y cells: protection against neurotoxicant-mediated cytotoxicity 2013 571 Evidence suggests oxidative and electrophilic stress as a major factor contributing to the neuronal cell death in neurodegenerative disorders, especially Parkinson's disease (PD). Early depletion in the levels of thiol antioxidant glutathione (GSH), ...
Studies of environmental pollutant acrolein-induced endothelial dysfunction: the role of glutathione and nf-kappab 2015 484 Environmental pollutant exposure has gained considerable attention as a potential risk factor contributing towards cardiovascular diseases (CVDs). Acrolein is a highly reactive electrophilic aldehyde known for its ubiquitous presence in the atmospher...
Carbon nanodot cellular uptake and modulation of Tumor necrosis factor-alpha-induced endothelial dysfunction 2018 147 In the past forty years, we have advanced our understanding of cardiovascular pathology through epidemiological and molecular studies. Atherosclerosis is one of the main cardiovascular diseases, which is also an underlying cause of more severe cardio...
Carbon nanodots in endothelial cells and C57BL/6 mice: a study of toxicity and anti-inflammatory effect 2018 281 The advancement of therapy for cardiovascular disease (CVD) is paramount to public health, as it is the leading global cause of mortality [1]. Nanomedicine provides new opportunities in the ongoing efforts to reduce the economic and healthcare conseq...
Investigation of endothelial cell injury and dysfunction induced by air pollutant benzo-a-pyrene-1,6-quinone: implications in chemical atherogenesis 2018 78 Cardiovascular diseases (CVD) are the leading cause of death for men and women in the USA, and growing evidence has led to an increase in concern about the detrimental effect of airborne particulate matter (PM) on health and its relation to the devel...
Protection of HepG2 cells from acrolein toxicity by CDDO-Im via glutathione-mediated mechanism 2013 2061 Acrolein is an environmental toxicant, mainly found in smoke released from incomplete combustion of organic matter. The compound is ubiquitously found in endogenous as well as exogenous environment. Several studies showed that exposure to acrolein ca...
Cellular Uptake of Carbon Nanodots in THP-1 Human Monocytes 2019 211 Cardiovascular disease (CVD) is the leading cause of death worldwide. Many types of treatment options are currently available but include side effects that inhibit quality living for many people. Carbon nanodots are novel carbon nanoparticles with si...
Roles of endothelial dysfunction and injury in mercury-induced cardiotoxicity 2019 159 Cardiovascular disease (CVD) is the leading global cause of mortality and morbidity and presents a significant economic impact in the form of healthcare costs. The development of cardiovascular disease has many facets ranging from unhealthy lifestyle...
Doxorubicin-induced cytotoxicity in rat myocardial H9c2 cells: the roles of reactive oxygen species and redox balance 2017 877 Doxorubicin (Dox) is one of the most potent anti-neoplastic agents approved by the Food and Drug Administration. Its efficacy, however, is limited due to its well-documented cardiotoxic side effect. Since the first observation of this dosage-dependen...
A study of the effect of carbon nanodots on proinflammatory cytokine TNF-a induced endothelial dysfunction. 2020 21 Cardiovascular disease (CVD) has become an increasingly important topic in the field of medical research due to the steadily increasing rates of mortality caused by this disease [1]. With recent advancements in nanotechnology, a push for new, novel t...
Modulation of macrophage polarization by carbon nanodots 2020 30 Atherosclerosis represents an ever-present global concern, as it is a leading cause of cardiovascular disease, and an immense public welfare issue. Macrophages play a key role in the onset of the disease state. Free oxygen radicals modify low-densiti...
Carbon nanodot uptake and their effects on macrophages upon challenge with oxidized LDL and TNF-alpha 2019 70 Atherosclerosis, a leading cause of cardiovascular disease worldwide, represents a global concern because of its large economic and public welfare burden. Macrophages play important physiological and pathological roles in the development of atheroscl...
In vitro and in vivo roles of 3H-1,2-dithiole-3-thione in lipopolysaccharide-induced toxicity and inflammatory injury 2021 46 Lipopolysaccharide (LPS) is a bacterial endotoxin known for being critical in triggering septic shock. It is widely used for studies to understand systemic inflammation that mimics the inflammatory storm of human sepsis patients. 3H-1,2-dithiole-3-th...
Upregulation of ROS detoxification genes by triterpenoid CDDO-Im in macrophages: protection against lipopolysaccharide-induced inflammatory injury 2019 132 Dysregulated response by the body towards an infection leads to tissue and organ damage is known as sepsis. Currently, approximately 18 million people worldwide are affected by this deadly disease annually. Septic shock, a severe form of sepsis, cont...