Croatt, Mitchell

uncg

There are 9 item/s.

TitleDateViewsBrief Description
Synthesis of potential potent antagonist of G-Protein coupled receptors 2016 122 GPR55, is a G-protein coupled receptor (GPCR), that was first discovered in 1990 and deorphanized in 2006. The homology model of the receptor in the active and inactive state is based off of the ß – adrenergic receptor. A potent agonist of GPR55 is t...
Synthesis and biological evaluation of potent neuroprotective agents against stroke and research on a novel type of decarboxylation reaction 2017 175 Isocarbacyclin is a valuable synthetic target that has been recognized as a potential neuroprotective agent against ischemic stroke. Herein we describe a step-economical synthesis of isocarbacyclin in an enantioselective fashion. The synthetic route ...
Design and development of novel reactions utilizing dienes and carbene intermediates 2020 55 The design and development of novel reactions are long-standing goals within the synthetic community. Specifically, reactions that can give molecularly complex products through the manipulation of readily available starting materials are of considera...
Protodecarboxylation of ß-keto-acrylates and synthesis of isomaleimides by dehydration of maleamic acids using methanesulfonyl chloride 2021 32 The development of unique reaction conditions for the protodecarboxylation of P-keto-acrylic acids is described. This expansion on previous work ameliorates the requirement of added water, affording a homogeneous reaction system. As an unexpected dis...
Palladium catalyzed dehydration of primary amides: a step economical synthesis of Vildagliptin 2021 94 The development of reactions that facilitate a concise path to chemical complexity has long been a focus within the synthetic community. Specifically, the use of readily available starting materials towards efficient routes to chemically relevant mol...
Approaches towards the biomimetic synthesis of 9-hydroxypinoresinol analogs: a stepping point in the development of a new anti-seizure drug 2013 2051 A recently isolated natural compound, Petaslignolide A, from the leaves of Petasites japonicas, has shown to be an effective neuroprotecting agent because of its antioxidant and anti-seizure activity. Recent studies have shown that the anti-seizure a...
Investigations in the synthesis of isocarbacyclin analogs involving transition metal catalysis with explorations into palladium catalyzed decarboxylation. 2013 1537 Isocarbacyclin, a synthetic form of prostacyclin, has been recognized as a potential neuroprotective drug which could be used for patients of ischaemic stroke. The first goal described in this thesis was to create a new set of analogs of isocarbacycl...
Design, synthesis and biological evaluation of GPR55 agonists and resorcylic acid lactone-based analogues as TAK-1 inhibi 2015 783 GPR55 is a potential target for treating various illnesses. Inhibition of this membrane-bound G protein-coupled receptor may potentially alleviate inflammatory and neuropathic pain and treat osteoporosis and cancer. Radiolabelling of a potent and sel...
Design, synthesis, and structure-activity relationships of GPR35 agonists and antagonists and design, synthesis, and anti-microbial evaluation of pyrazole derivatives 2015 497 GPR35, a G protein-coupled receptor (GPCR), was discovered and specified as an orphan receptor in 1998. GPR35 has been described as a prospective therapeutic target as a result of its association with many diseases including type-2 diabetes, nocicept...