Petersen, Kimberly

uncg

There are 9 item/s.

TitleDateViewsBrief Description
Efforts towards the formal synthesis of bakuchiol via small molecule manipulation 2014 875 Bakuchiol is a monoterpinoid compound found mainly in the seeds of Psoralea coryfolia Linn, which is indigenous to Southeast Asia. Since its discovery and isolation in 1967, it has been reported to contain a multitude of health benefits. It exhibits ...
Formation of bicycles and spirocycles via desymmetrization 2017 548 Biologically active naturally produced and synthetic compounds often feature chiral centers and heteroatoms. The inclusion of these heteroatoms in cyclic motifs such as lactones and lactams with specific stereochemistry is common. While naturally pro...
Asymmetric synthesis of enantioenriched spirocycles via a chiral Brønsted acid catalyzed desymmetrization 2019 225 Asymmetric methodologies are very important as they allow chemists to produce significant quantities of complex chiral molecules as enantiopure or enantioenriched compounds. The Petersen group has previously developed chiral Brønsted acid catalyzed d...
A novel application of organocatalysis for the synthesis of six-membered ring lactones 2019 47 Brønsted acid catalysis is an emerging area of organocatalysis. The small and labile nature of an acidic hydrogen atom and its interaction with substrates containing basic functional groups allows for the preparation of diverse compounds. When the su...
Facile synthesis of enantioenriched hydroxy esters via Brønsted acid catalyzed kinetic resolution 2014 1295 The synthesis of natural products is a growing area of research within the field of chemistry. Compounds are extracted from sources such as fungi, plants, algae, and other natural sources. The compounds that are biologically active often need to be s...
Investigation into the mechanism of catalysis for the kinetic resolution of a,a-Disubstituted y-Hydroxy Esters 2018 56 The synthesis of enantioenriched, biologically active compounds is a vital area of interest for synthetic chemists. The lactone motif is found in several biologically important molecules, and the development of kinetic resolutions capable of producin...
Diastereoselective cyclization of lactones via Brønsted acid catalysis 2020 43 Chiral molecules play a vital role in supporting biologically effective drugs. Consequently, a majority of pharmaceutical companies seek to isolate the enantiomers of molecules in drug design. Enantioselective synthesis can be a valuable tool for cre...
Formation of standards for biosynthetic studies of bacillaene and difficidin and synthesis of novel enantioenriched heterocycle via desymmetrization 2021 15 Polyketide synthases are multidomain enzymes that act as chemical assembly lines. Polyketides produced by polyketide synthases play a vital role within bacteria, such as providing it the necessary protection to defend against other bacteria. Two poly...
Enantioselective cyclization of symmetric diesters 2016 633 Two important facets that are found in many biologically active compounds and complex natural products are chirality and heterocyclic motifs, in particular lactones and lactams. Biologically active compounds found in nature often need to be synthesiz...