Katula, Karen

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There are 15 item/s.

TitleDateViewsBrief Description
Effects of altered folate metabolism on specific gene expression in the developing Xenopus embryo 2006 2756 "Approximately 1 out of every 2000 births in the United States is affected by neural tube defects. The most well-known environmental cause of neural tube malformation is folate deficiency in pregnant women. The underlying mechanism for this relation...
Regulation of dickkopf-1(Dkk-1) promoter sequences under various growth conditions 2006 1885 "The goal of this study was to determine what region of the Dkk-1 promoter was required for expression of the Dkk-1 gene under different growth conditions. Dkk-1 promoter activity was analyzed in NIH3T3 cell lines stably transfected with luciferase ...
Role of DNA methylation in WNT5A Promoter B expression in Osteosarcoma (SaOS-2) cells. 2013 978 WNT5A, a member of the WNT family of secreted proteins, activates the non-canonical WNT pathway, regulates developmental events and is involved in tissue homeostasis. Misregulation of WNT5A has been associated with various types of cancer including p...
Functional distinctions between two isoforms of WNT5A 2016 761 WNT5A is a secreted protein ligand with important roles in development, adult tissue homeostasis, and many basic cellular functions. In cancers, aberrant WNT5A signaling is often observed. This study focused on potential functional differences betwee...
Characterization and regulation of Wnt5a alternate promoters A and B 2011 2943 WNT5A is an extracellular glycoprotein that activates several Wnt signaling pathways important in cancer. Significantly, Wnt5a expression is altered in numerous cancers. Little is known about Wnt5a gene regulation but current data indicate that misre...
Aberrant DNA methylation and patterns of histone modifications at the WNT5A Promoter B in osteosarcoma cells 2014 1507 WNT5A is a secreted ligand involved in differentiation, proliferation, cell movement and apoptosis. WNT5A is often misregulated in cancer and is known to be involved in cancer metastasis. The focus of this study was on the possible epigenetic regulat...
Evidence of functional distinction between WNT5A Isoform A and Isoform B in osteosarcoma cells 2014 1823 WNT5A is a secreted ligand involved in differentiation, proliferation, cell movement, and apoptosis. Various studies have shown WNT5A misregulation in cancer and that it can act as both a tumor suppressor, and oncogene. The WNT5A gene has two transcr...
Identification of drug sensitive gene motifs using “epigenetic profiles” derived from bioinformatics databases 2016 1023 The use of epigenetic modifying drugs such as DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi) is becoming more common in the treatment of cancer. Currently, there is a profound interest in determining predictive bi...
The Effect of Folate Deficiency on the Wnt Signaling Pathway 2008 2460 Folate is an essential dietary vitamin involved in methylation reactions and DNA synthesis. Insufficient dietary folate has been associated with various developmental and adult diseases such as neural tube defects and colorectal cancer. The basis for...
The effects of folate deficiency on E-cadherin and ß-catenin in colon epithelial cells. 2009 1602 Folate deficiency has been linked to multiple health problems including neural tube defects and cancer, especially colorectal cancer. Folate is an essential dietary vitamin that is required for DNA synthesis and cellular methylation reactions. The me...
Expression of Wnt5a alternative promoters A and B during cancer progression and cellular differentiation 2012 2422 WNT5A is a secreted glycoprotein that plays an important role in cellular differentiation, cell homeostasis and development. It is also misregulated in numerous cancer cell types. The Wnt5a gene generates multiple transcripts from distinct promoters ...
Role of WNT5A isoform L(A) and isoform S(B) during osteoblast differentiation 2018 313 WNT signaling has been characterized as a critical signaling cascade in many aspects of embryogenesis, cell differentiation and tissue homeostasis. Appropriate WNT signaling requires dynamic expression of WNTs along with their receptors, ensuring a p...
The effects of chronic glyphosate exposure on osteoblast cell function 2020 180 Glyphosate is the functional component of the herbicide, RoundUp®. Although considered safe for humans by the US Environmental Protection Agency (EPA), it has been classified as “probably carcinogenic to man” by the International Agency for Research ...
Are the WNT5A isoforms functionally distinct? - promoter and signaling pathway analyses 2018 914 WNT5A is a secreted glycoprotein that binds to both canonical and non-canonical Wnt receptors and has important roles in morphogenesis (e.g., anterior-posterior axis elongation and limb formation) and differentiation (e.g., bone and cartilage). On a ...
Possible involvement of NF-?B in the response of cells to folate deficiency. 2009 1297 Folate, a water soluble B vitamin, serves as a methyl donor for the synthesis of nucleotides and methionine. Folate deficiency has been linked to a variety of health problems that include developmental defects, cancer and neurological diseases. The r...