Kepley, Christopher

uncg

There are 9 item/s.

TitleDateViewsBrief Description
Differentiation of functional human mast cells from adipose derived stem cells and their application in allergo-oncology and the treatment of breast cancer 2018 723 Mast Cells are important yet poorly understood components of the immune system. Study of mast cells has been hampered by difficulty in obtaining primary cells, the lack of functional cell lines and the high degree of dissimilarity between human and m...
Investigating the mechanism of action of a new gold based therapeutic with re-myelinating properties 2019 40 The focus of this thesis is on in vitro studies of a new therapeutic gold nanocrystal CNM-Au8, manufactured under cGMP process using a patented electro-crystal-chemistry process by Clene Nanomedicine, Inc (www.clene.com), a clinical-stage biopharmace...
Studies examining the infectivity of Human Immunodeficiency Virus (HIV) on human immune cells 2017 262 Human immunodeficiency virus (HIV) establishes a latent infection in cells to ensure a persistent infection throughout an infected individual’s life. HIV can establish this latent infection in a variety of cells. Highly Active Anti-Retroviral Treatme...
Studies examining the efficacy of therapeutically enhanced human mast cells as a cancer immunotherapy 2021 93 The emergence of cancer immunotherapies utilizing adoptive cell transfer (ACT) continues to be one of the most promising strategies for cancer treatment. Mast cells (MCs), ubiquitous tissue cells most commonly associated with Type I hypersensitivity,...
Studies examining the anti-aging effects of fullerenes 2017 238 Research on aging has been invigorated by recent findings suggesting certain mutations in various invertebrate models (yeast, worms, and flies) can slow down aging and improve healthspan. Reactive Oxygen Species (ROS) production and manipulation of t...
Exploratory studies into the therapeutic and diagnostic capability of blood from the horseshoe crab, Limulus polyphemus 2020 91 Antimicrobial resistance is a major health challenge that causes serious morbidity and mortality worldwide. The overuse of antibiotics has sped up the rise of resistant pathogens and rendered many antibiotics useless. There has been a worldwide push ...
Fullerenes and their potential in nanomedicine 2015 2597 Carboxyfullerenes are closed carbon spheres which are being actively pursued globally for a wide range of applications. Their inherent properties and ability to be functionalized with side-chains results in nearly limitless new chemical structures ma...
Designing and testing a molecularly targeted glioblastoma theranostic: experimental and computational studies 2018 539 With an extremely poor patient prognosis glioblastoma multiforme (GBM) is one of the most aggressive forms of brain tumor with a median patient survival of less than 15 months. While new diagnostic and therapeutic approaches continue to emerge, the p...
Studies examining mast cells, nanomaterials, and immunoglobulins to treat breast cancer, atherosclerosis, and allergies 2019 319 Mast cells (MC) are important immune sentinels found in most tissue and widely recognized for their role as mediators of Type I hypersensitivity. However, they also secrete anti-cancer mediators such as tumor necrosis factor alpha (TNF-a) and granulo...