The Relation of Documented Coronary Artery Disease to Levels of Total Cholesterol and High-Density Lipoprotein Cholesterol

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
H. William Gruchow, Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Recommendations for identifying persons at high risk for coronary heart disease are based primarily on levels of total and low-density lipoprotein cholesterol. We examined whether, given knowledge of these levels, information on the high-density lipoprotein cholesterol level would improve the prediction of arteriographically documented coronary artery disease among 591 men. We found that even at levels of total and low-density lipoprotein cholesterol considered desirable, high-density lipoprotein cholesterol was inversely related to disease severity. For example, among the 112 men with a total cholesterol level <180 mg per dl, the mean occlusion score (representing the overall severity of disease) was 107 among men with a high-density lipoprotein cholesterol level =30 mg per dl vs a mean score of 52 among men with levels =45 mg per dl. Furthermore, men with low levels of both low-density lipoprotein cholesterol (<110 mg per dl) and high-density lipoprotein cholesterol (=30 mg per dl) had as much occlusive disease as did men with high levels of both lipoprotein fractions. Given information on the ratio of high-density lipoprotein cholesterol to total cholesterol, the actual levels of the lipoprotein fractions did not improve disease prediction. Our results emphasize the importance of considering high-density lipoprotein cholesterol when assessing coronary heart disease risk. Keywords: cholesterol levels, HDL lipoproteins, LDL lipoproteins, coronary artery disease, lipids.

Additional Information

Freedman DS, Croft JB, Anderson AJ, Byers T, Jacobsen SJ, Gruchow HW, Barboriak JJ. The relation of documented coronary artery disease to levels of total and high-density lipoprotein cholesterol. Journal of Epidemiology 5:80-87, 1994.
Language: English
Date: 1994
Coronary artery disease, Cholesterol, Lipoprotein, cholesterol, Coronary heart disease

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