Antioxidant capacity of Nitrogen and Sulfur co-doped carbon nanodots

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Zhenquan Jia, Assistant Professor (Creator)
Jianjun Wei, Associate Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Carbon nanodots (CNDs) have shown potential for antioxidative activity at the cellular level. Here we applied a facile hydrothermal method to prepare fluorescent nitrogen and sulfur (N,S-) codoped CNDs using a-lipoic acid, citric acid, and urea as precursor molecules. This work describes a comprehensive study for exploring their antioxidation activity using UV–vis absorption and electrochemistry measurements of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•), as well as a lucigenin chemiluminescence (lucigenin-CL) assay. The lucigenin-CL assay detects superoxide anion radicals, i.e., reactive oxygen species (ROS) produced through the xanthine/xanthine oxidase (XO) reaction. The electrochemically derived relationship between the unreacted nitrogen-centered DPPH• and CND concentrations agrees with that obtained from UV–vis measurements. A reaction pathway for the ROS antioxidative reaction of N,S-codoped CNDs is proposed. These findings should aid in the development of N,S-codoped CNDs for practical use in biomedical applications. [The original abstract for this article contains (characters/images) that cannot be displayed here. Please click on the link below to read the full abstract and article.]

Additional Information

ACS Applied Nano Materials, 2018, 1(6) 2699-2708. DOI: 10.1021/acsanm.8b00404
Language: English
Date: 2018
carbon nanodots, nitrogen and sulfur doping, antioxidation

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