A polymorphism in human estrogen-related receptor beta (ESRRß) predicts audiometric temporary threshold shift

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Kristine Lundgren, Associate Professor (Creator)
Scott J. Richter, Professor (Creator)
Denise A. Tucker, Associate Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: Objective: A non-synonymous single nucleotide polymorphism (rs61742642; C to T, P386S) in the ligand-binding domain of human estrogen-related receptor beta (ESRRß) showed possible association to noise-induced hearing loss (NIHL) in our previous study. Design: This study was conducted to examine the effect of the ESRRß rs61742642 T variant on temporary threshold shift (TTS). TTS was induced by 10?minutes of exposure to audiometric narrow-band noise centered at 2000?Hz. Hearing thresholds and distortion product otoacoustic emissions input output function (DP IO) at 2000, 3000, and 4000?Hz were measured before and after the noise exposure. Study sample: Nineteen participants with rs61742642 CT genotype and 40 participants with rs61742642?CC genotype were recruited for the study. Results: Participants with the CT genotype acquired a significantly greater TTS without convincing evidence of greater DP IO temporary level shift (DPTLS) compared to participants with the CC genotype. Conclusion: The results indicated that the ESRRß polymorphism is associated with TTS. Future studies were recommended to explore molecular pathways leading to increased susceptibility to NIHL.

Additional Information

International Journal of Audiology, 55(10): 571–579.
Language: English
Date: 2016
Noise-induced hearing loss (NIHL), Estrogen-Related Receptor Beta (ESRRß), Temporary Threshold Shift (TTS), Otoacoustic Emissions (OAE), Single Nucleotide Polymorphism (SNP)

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