Functional distinctions between two isoforms of WNT5A

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
III. Carl J. Manner (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:
Karen Katula

Abstract: WNT5A is a secreted protein ligand with important roles in development, adult tissue homeostasis, and many basic cellular functions. In cancers, aberrant WNT5A signaling is often observed. This study focused on potential functional differences between two isoforms of this protein, on potential signaling differences between these two isoforms, and on differential expression of these isoforms in the context of mouse embryonic development. This study found that these isoforms both had no effect on either cellular migration or invasion in HCT116, contrary to reports published in the literature. This study also found that both these isoforms had no detectable effect on activation of terminal effector molecules in the PCP/CE pathway or in the Wnt/Ca2+ pathway. In a murine model of embryonic development, we observed that WNT5A isoforms were differentially regulated. Overall, the findings of this study suggest that WNT5A encodes functionally distinct protein isoforms which may play a role in enabling the orchestration of a complex series of biological events during embryonic development.

Additional Information

Language: English
Date: 2016
Cancer, Colorectal Cancer, Embryonic Development, Metastasis, WNT5A, Wnt Signaling
Wnt proteins
Cellular signal transduction
Colon (Anatomy) $x Cancer
Rectum $x Cancer

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