Sensorineural hearing loss and volatile organic compound metabolites in urine

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
William N. Dudley, Professor Public Health Education (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Purpose: Oxidative stress in the auditory system contributes to acquired sensorineural hearing loss. Systemic oxidative stress, which may predict auditory oxidative stress, can be assessed by measuring volatile organic compound metabolite concentrations in urine. The purpose of this retrospective study was to determine if hearing decreased in those with higher concentrations of urinary volatile organic compound metabolites. Materials and methods: Audiometric, demographic, and metabolite concentration data were downloaded from the 2011–2012 cycle of the U.S. National Health and Nutritional Examination Survey. Participants were first grouped by reported noise exposure. For each metabolite, an analysis of covariance was used to look for differences in age-adjusted hearing loss among urinary volatile organic compound metabolite concentration groups. Participants were grouped into quartiles based on concentration for each metabolite separately because many individuals were at the lower limit of concentration detection for several metabolites, leading to a non-normal distribution. Results: Age-adjusted high-frequency pure-tone thresholds were significantly (FDR?

Additional Information

American Journal of Otolaryngology. 2019 May - Jun;40(3):409-412
Language: English
Date: 2019
Sensorineural hearing loss, Volatile organic compounds, Mercapturic acids

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