Studies examining mast cells, nanomaterials, and immunoglobulins to treat breast cancer, atherosclerosis, and allergies

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Michael George Elias (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:
Christopher Kepley

Abstract: Mast cells (MC) are important immune sentinels found in most tissue and widely recognized for their role as mediators of Type I hypersensitivity. However, they also secrete anti-cancer mediators such as tumor necrosis factor alpha (TNF-a) and granulocyte-macrophage colony-stimulating factor (GM-CSF). In addition, MC and their secreted cytokines play a role in the development of atherosclerotic plaque and allergic reactions. Herein, it is demonstrated that MC differentiated from adipose derived stem cells, target and induce breast cancer cell apoptosis via an IgE-mediated targeting method. It also demonstrated that the fullerene derivatives (FDs) inhibit atherosclerotic plaque formation by reducing MC cytokine release. Finally, the demonstration of a low-affinity anti-IgE antibody, that binds to and desensitizes MC, can be used for allergy therapy is exhibited herein. [This abstract has been edited to remove characters that will not display in this system. Please see the PDF for the full abstract.]

Additional Information

Language: English
Date: 2019
Allergo-Oncology, Cancer, Cytokine, HER2, IgE, Mast Cell
Mast cells $x Immunology
Nanostructured materials
Immunoglobulin E

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