Postpartum Cervical Repair In Mice: A Morphological Characterization And Potential Role For Angiogenic Factors

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Dr.. Chishimba Nathan Mowa, Associate Professor (Creator)
Appalachian State University (ASU )
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Abstract: The cervix undergoes marked mechanical trauma during delivery of the baby at birth. As such, a timely and complete tissue repair postpartum is necessary to prevent obstetrical complications, such as cervicitis, ectropion, hemorrhage, repeated miscarriages or abortions and possibly pre- term labor and malignancies. However, our knowledge of normal cervical repair is currently incomplete and factors that influence repair are unclear. Here, we characterize the morphological and angiogenic profile of postpartum repair in mice cervix during the first 48 h of postpartum. The key findings presented here are: (1) cervical epithelial folds and size are diminished during the first 48 h of postpartum repair, (2) hypoxic inducible factor 1a, vascular endothelial growth factor (VEGF), and VEGF receptor 1 expression are pronounced early in postpartum cervical repair, and (3) VEGF receptor 2 gene and protein expressions are variable. We conclude that postpartum cervical repair involves gross and microscopic changes and is linked to expression of angiogenic factors. Future studies will assess the suitability of these factors, identified in the present study, as potential markers for determining the phase of postpartum cervical repair in obstetrical complications, such as cervical lacerations.

Additional Information

Chishimba, Mowa & Takako, Ohashi & Stanley, Robert (2015) "Postpartum Cervical Repair In Mice: A Morphological Characterization And Potential Role For Angiogenic Factors." Cell and Tissue Research vol. 362 issue. 1 pp. 253-263 [DOI: 10.1007/s00441-015-2184-x] Version of Record Available At
Language: English
Date: 2015
Postpartum repair, Cervical remodeling, VEGF, Mice, VEGF receptors

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