Flavonol Intake and Cognitive Decline in Middle-Aged Adults

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Martin Root Ph.D, Associate Professor (Creator)
Appalachian State University (ASU )
Web Site: https://library.appstate.edu/

Abstract: Cognitive decline occurs with age and may be slowed by dietary measures, including increased intake of dietary phytochemicals. However, evidence from large and long-term studies of flavonol intake is limited. Dietary intakes of flavonols were assessed from a large biracial study of 10,041 subjects, aged 45–64, by analysis of a food frequency ques tionnaire administered at visit 1 of triennial visits.Cognitive function was assessed at visits 2 and 4 with the following three cognitive performance tests: the delayed word recall test, the revised Wechsler Adult Intelligence Scale digit symbol subtest, and the word fluency test of the Multilingual Aphasia Examination. The change in each score over 6 years was calculated, and a combined standardized change score was calculated. Generalized linear models controlled for age, ethnicity, gender, education level, energy intake, current smoking, physical activity,body mass index, diabetes, and vitamin C intake. Total flavonols across quintiles of intake were positively associated with preserved combined cognitive function (P < .001). This pattern with preserved combined cognitive function was consistent for the three major individual flavonols in the diet, myricetin, kaempferol, and quercetin (each P < .001). The positive association with total flavonols was strongest for the digit symbol subtest (P < .001). In this cohort, flavonol intake was correlated with protected cognitive function over time

Additional Information

Martin Root, Erin Ravine, and Anne Harper(2015) Flavonol Intake and Cognitive Decline in Middle-Aged Adults. JOURNAL OF MEDICINAL FOOD [DOI 10.1089]
Language: English
Date: 2015
flavonol, intake, cognitive, decline, middle-aged,

Email this document to