Increased Long-Term Mortality among Black CABG Patients Receiving Preoperative Inotropic Agents

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Ethan J. Anderson (Creator)
W. Randolph Chitwood (Creator)
Patricia B. Crane (Creator)
Stephen W. Davies (Creator)
Jimmy T. Efird (Creator)
T. Bruce Ferguson (Creator)
William F. Griffin (Creator)
Zahra J. Iqbal (Creator)
Linda Kindell (Creator)
Nathaniel T. Koutlas (Creator)
A Kypson (Creator)
Hope Landrine (Creator)
Daniel F. Sarpong (Creator)
Iulia Vann (Creator)
East Carolina University (ECU )
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Abstract: The aim of this study was to examine racial differences in long-term mortality after coronary artery bypass grafting (CABG), stratified by preoperative use of inotropic agents. Black and white patients who required preoperative inotropic support prior to undergoing CABG procedures between 1992 and 2011 were compared. Mortality probabilities were computed using the Kaplan-Meier product-limit method. Hazard ratios (HR) and 95% confidence intervals (CI) were computed using a Cox regression model. A total of 15,765 patients underwent CABG, of whom 211 received preoperative inotropic agents within 48 hours of surgery. Long-term mortality differed by race (black versus white) among preoperative inotropic category (inotropes: adjusted HR = 1.6, 95% CI = 1.009-2.4; no inotropes: adjusted HR = 1.15, 95% CI = 1.08-1.2; P(interaction) < 0.0001). Our study identified an independent preoperative risk-factor for long-term mortality among blacks receiving CABG. This outcome provides information that may be useful for surgeons, primary care providers, and their patients.

Additional Information

International Journal of Environmental Research and Public Health; 12:7 p. 7478-7490
Language: English
Date: 2015
cardiac surgery, mortality, disparities, heart failure, heart disease, inotropes

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