The Effect of Casein Protein Prior to Sleep on Fat Metabolism in Obese Men

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Amber W.,Cappadona,Stacy R.,Panton,Lynn B.,Allman,Britta Kinsey (Creator)
East Carolina University (ECU )
Web Site:

Abstract: We have previously shown that ingesting protein at night before sleep is either beneficialor non-detrimental to metabolism, health, and body composition in obese women. However, theovernight protein-induced lipolytic actions and mechanism for improved metabolism and bodycomposition have not been fully established. Therefore, in a crossover design, twelve obese men(age, 27.0 ˘ 2.2 years) were randomly assigned to ingest (within 30 min of sleep) casein protein(CAS, 120 kcal) or a non-nutritive placebo (PLA) before going to sleep. Markers of fat metabolism(lipolysis, substrate utilization, growth hormone), insulin, glucose, resting energy expenditure (REE),and appetite (questionnaire and ghrelin) were measured. During sleep and the next morning,interstitial glycerol from the subcutaneous abdominal adipose tissue (SCAAT) was measured usingmicrodialysis. There were no differences in SCAAT glycerol (overnight: CAS, 177.4 ˘ 26.7; PLA,183.8 ˘ 20.2 µmol/L; morning: CAS, 171.6 ˘ 19.1; PLA, 161.5 ˘ 18.6 µmol/L), substrate utilization,REE, or any blood markers between CAS and PLA. Desire to eat was greater for CAS comparedto baseline (p = 0.03), but not different from PLA (baseline: 39 ˘ 6, CAS: 62 ˘ 8, PLA: 55 ˘ 5 mm).CAS consumption before sleep did not affect fat or glucose metabolism, REE, or suppress appetitein hyperinsulemic obese men. CAS may be consumed before sleep without impeding overnight ormorning fat metabolism in young, obese men.

Additional Information

Language: English
Date: 2016
nighttime eating; sleep; obesity; microdialysis; appetite; casein

Email this document to

This item references:

TitleLocation & LinkType of Relationship
The Effect of Casein Protein Prior to Sleep on Fat Metabolism in Obese Men described resource references, cites, or otherwise points to the related resource.