Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Rick J. Alleman (Creator)
David A. Brown (Creator)
Luke M. Stewart (Creator)
Alvin M. Tsang (Creator)
East Carolina University (ECU )
Web Site: http://www.ecu.edu/lib/

Abstract: Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that exercise, specifically characterized by lower myocardial infarction and arrhythmia. Despite the clear benefits, the underlying cellular and molecular mechanisms that are responsible for exercise preconditioning are not fully understood. In particular, the adaptive signaling events that occur during exercise to “trigger” cardioprotection represent emerging paradigms. In this review, we discuss recent studies that have identified several different factors that appear to initiate exercise preconditioning. We summarize the evidence for and against specific cellular factors in triggering exercise adaptations and identify areas for future study.

Additional Information

Dose-Response; 13:1 p. 1-19
Language: English
Date: 2015
exercise, mitochondria, cardiac, heart, Preconditioning

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Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?http://hdl.handle.net/10342/5794The described resource references, cites, or otherwise points to the related resource.