Construct validity of a continuous metabolic syndrome score in children

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Joseph E. Donnelly (Creator)
Katrina D. DuBose (Creator)
Joey C. Eisenmann (Creator)
Kelly R. Laurson (Creator)
Bryan K. Smith (Creator)
East Carolina University (ECU )
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Abstract: Objective: The primary purpose of this study was to examine the construct validity of a continuous metabolic syndrome score (cMetS) in children. The secondary purpose was to identify a cutpoint value(s) for an adverse cMetS based on receiver operating characteristic (ROC) curve analysis. Methods: 378 children aged 7 to 9 years were assessed for the metabolic syndrome which was determined by ge-modified cutpoints. High-density-lipoprotein cholesterol triglycerides the homeostasis assessment model of insulin resistance mean arterial pressure and waist circumference were used to create a cMetS for each subject. Results: About half of the subjects did not possess any risk factors while about 5% possessed the metabolic yndrome. There was a graded relationship between the cMetS and the number of adverse risk factors. The cMetS was lowest in the group with no adverse risk factors (-1.59 ± 1.76) and highest in those possessing the metabolic syndrome (≥3 risk factors) (7.05 ± 2.73). The cutoff level yielding the maximal sensitivity and specificity for predicting the presence of the metabolic syndrome was a cMetS of 3.72 (sensitivity = 100% specificity = 93.9% nd the area of the curve = 0.978 (0.957-0.990 95% confidence intervals). Conclusion: The results demonstrate the construct validity for the cMetS in children. Since there are several drawbacks to identifying a single cut-point value for the cMetS based on this sample we urge researchers to use the approach herein to validate and create a cMetS that is specific to their study population. Originally published Diabetology and Metabolic Syndrome Vol. 2 No. 8 Jan 2010

Additional Information

Diabetology and Metabolic Syndrome. 2:8(January 2010).
Language: English
Date: 2011
metabolic syndrome, construct validity, cutpoint values, Children

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