Exploring the anti-cancer properties of novel Rhenium-based compounds

ECSU Author/Contributor (non-ECSU co-authors, if there are any, appear on document)
Jazmine Cuffee, student (Creator)
Joseph Hedley, student (Creator)
Kayla Johnston, student (Creator)
Christopher Krauss (Creator)
Santosh Mandal, student (Creator)
Jeffrey Rousch, Professor (Creator)
Sarah Wisniewski, student (Creator)
Elizabeth City State University (ECSU )
Web Site: https://www.ecsu.edu/academics/library/index.html

Abstract: Despite ongoing research, cancer remains a lethal disease claiming the lives of over 600,000 people in the US alone each year. While there are treatments available, many of them are toxic to healthy tissues in addition to the tumors they are designed to kill. Using Rhenium as the core for compounds can enable anti-cancer properties while also having lowered toxicity towards non-cancerous tissues in the human body. Here we studied the anti-cancer properties of 10 rhenium-based compounds by exposing cancer cell lines to the compounds for 48 hours before using an MTT assay to measure viability. The compounds showing the most promise was then tested further to see if the compounds could block spheroid formation. These spheroids serve as an indicator for stem-cell-like properties in cancers that can lead to relapses if left untreated.

Additional Information

Language: English
Date: 2021
anti-cancer properties, cancer, compounds, Rhenium

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