Immune And Inflammation Responses To A 3-Day Period Of Intensified Running Versus Cycling

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Dru Henson Ph.D., Professor & Assistant Dean (Creator)
Dr.. David Nieman, Director (Creator)
Andrew Shanely Ph.D, Associate Professor (Creator)
Appalachian State University (ASU )
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Abstract: Functional overreaching has been linked to alterations in immunity and host pathogen defense, but little is known as to whether or not running and cycling evoke different responses. This study compared inflammation, muscle damage and soreness, and innate immune function responses to a 3-day period of intensified exercise in trained long distance runners (N = 13, age 34.4 +/- 2.4 year) and cyclists (N = 22, age 36.6 +/- 1.7 year, P = 0.452). Upper respiratory tract infection (URTI) symptomatology was monitored for 12 weeks using the Wisconsin Upper Respiratory Symptom Survey (WURSS), and subjects from both athletic groups came to the lab during week five and exercised 2.5 h/day for 3 days in a row at 70% VO2max. Blood samples were collected before and after the 3-day period of exercise, with recovery samples collected 1-, 14-, and 38 h-post-exercise. Samples were analyzed for muscle damage [creatine kinase (CK), myoglobin (MYO)], inflammation (CRP, IL-6, IL-8, IL-10, MCP), and innate immunity [granulocyte and monocyte phagocytosis (GR-PHAG and MO-PHAG) and oxidative burst activity (GR-OBA and MO-OBA)]. Runners compared to cyclists experienced significantly more muscle damage (CK 133% and MYO 404% higher post-3 days exercise), inflammation (CRP 87%, IL-6 256%, IL 8 61%, IL-10 32%, MCP 29%), and delayed onset of muscle soreness (DOMS, 87%). The 3-day period of exercise caused significant downturns in GR-PHAG, MO-PHAG, GR-OBA, MO-OBA by 14- and 38 h-recovery, but the pattern of change did not differ between groups. No group differences were measured for 12-week URTI severity (18.3 +/- 5.6 and 16.6 +/- 4.0, P = 0.803) and symptom scores (33.4 +/- 12.6 and 24.7 +/- 5.8, P = 0.477). These data indicate that a 3-day period of functional overreaching results in substantially more muscle damage and soreness, and systemic inflammation in runners compared to cyclists, but without group differences for 12-week URTI symptomatology and post-exercise decrements in innate immune function.

Additional Information

Dru A. Henson, David C. Nieman, Beibei Luo, Didier Dréau, R. Andrew Shanely, Dustin Dew & Mary Pat Meaney (2014) "Immune And Inflammation Responses To A 3-Day Period Of Intensified Running Versus Cycling" Brain, Behavior And Immunity Vol. 39 pp.180-185 [DOI 10.1016/j.bbi.2013.09.004] Version of Record Available From
Language: English
Date: 2016
exercise, immunology, muscle soreness, respiratory illness, cytokine

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