Influence Of Pistachios On Performance And Exercise-Induced Inflammation, Oxidative Stress, Immune Dysfunction, And Metabolite Shifts In Cyclists: A Randomized, Crossover Trial
- ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
- Dru Henson Ph.D., Professor & Assistant Dean (Creator)
- Dr.. David Nieman, Director (Creator)
- Institution
- Appalachian State University (ASU )
- Web Site: https://library.appstate.edu/
Abstract: Objectives: Pistachio nut ingestion (3 oz./d, two weeks) was tested for effects on exercise performance and 21-h post-exercise recovery from inflammation, oxidative stress, immune dysfunction, and metabolite shifts. Methods: Using a randomized, crossover approach, cyclists (N = 19) engaged in two 75-km time trials after 2-weeks pistachio or no pistachio supplementation, with a 2-week washout period. Subjects came to the lab in an overnight fasted state, and ingested water only or 3 oz. pistachios with water before and during exercise. Blood samples were collected 45 min pre-exercise, and immediately post-, 1.5-h post-, and 21-h post-exercise, and analyzed for plasma cytokines, C-reactive protein (CRP), F2-isoprostanes (F2-IsoP), granulocyte phagocytosis (GPHAG) and oxidative burst activity (GOBA), and shifts in metabolites. Results: Performance time for the 75-km time trial was 4.8% slower under pistachio conditions (2.8460.11 and 2.7160.07 h, respectively, P = 0.034). Significant time effects were shown for plasma cytokines, CRP, F2-IsoP, GPHAG, and GOBA, with few group differences. Metabolomics analysis revealed 423 detectable compounds of known identity, with significant interaction effects for 19 metabolites, especially raffinose, (12Z)-9,10-Dihydroxyoctadec-12-enoate (9,10-DiHOME), and sucrose. Dietary intake of raffinose was 2.1960.15 and 0.3560.08 mg/d during the pistachio and no pistachio periods, and metabolomics revealed that colon raffinose and sucrose translocated to the circulation during exercise due to increased gut permeability. The post-exercise increase in plasma raffinose correlated significantly with 9,10-DiHOME and other oxidative stress metabolites.Conclusions: In summary, 2-weeks pistachio nut ingestion was associated with reduced 75-km cycling time trial performance and increased post-exercise plasma levels of raffinose, sucrose, and metabolites related to leukotoxic effects and oxidative stress.
Influence Of Pistachios On Performance And Exercise-Induced Inflammation, Oxidative Stress, Immune Dysfunction, And Metabolite Shifts In Cyclists: A Randomized, Crossover Trial
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Additional Information
- Publication
- Dru Henson, David C. Nieman, Johannes Scherr, Beibei Luo, Mary Pat Meaney, Didier Dréau, Wei Sha, Dustin A. Dew, & Kirk L. Pappan (2014) "Influence Of Pistachios On Performance And Exercise-Induced Inflammation, Oxidative Stress, Immune Dysfunction, And Metabolite Shifts In Cyclists: A Randomized, Crossover Trial" PLOS ONE Vol. 9 Issue 11 Open Access Journal. Version of Record Available From www.journals.plos.org
- Language: English
- Date: 2014
- Keywords
- Health, Responses, Raffinose, Myoinositol, Responses, Linoleic-Acid