Effects Of Quercetin And EGCG On Mitochondrial Biogenesis And Immunity

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Dru Henson Ph.D., Professor & Assistant Dean (Creator)
Dr.. David Nieman, Director (Creator)
Andrew Shanely Ph.D, Associate Professor (Creator)
Appalachian State University (ASU )
Web Site: https://library.appstate.edu/

Abstract: Purpose: To test the influence of 1000 mg of quercetin (Q) with or without 120 mg of epigallocatechin 3-gallate (EGCG), 400 mg of isoquercetin, and 400 mg of eicosapentaenoic acid and docosahexaenoic acid (Q–EGCG) on exercise performance, muscle mitochondrial biogenesis, and changes in measures of immunity and inflammation before and after a 3-d period of heavy exertion. Methods: Trained cyclists (N = 39) were randomized to placebo (P), Q, or Q–EGCG and ingested supplements in a double- blinded fashion for 2 wk before, during, and 1 wk after a 3-d period in which subjects cycled for 3 hIdj1 at È57% Wmax. Blood, saliva, and muscle biopsy samples were collected before and after 2 wk of supplementation and immediately after the exercise bout on the third day. Blood and saliva samples were also collected 14 h after exercise. Results: Two-week supplementation resulted in a significant increase in plasma quercetin for Q and Q–EGCG and granulocyte oxidative burst activity (GOBA) in Q–EGCG. Immediately after the third exercise bout, significant decreases for C-reactive protein (CRP), and plasma interleukin 6 (IL-6) and interleukin 10 (IL-10) were measured in Q–EGCG compared with P. Granulocyte colony-stimulating factor and CRP were reduced in Q–EGCG 14 h after exercise. No group differences were measured in muscle messenger RNA expression for peroxisome proliferator-activated receptor F coactivator>, citrate synthase, or cytochrome c. Conclusions: Two-week supplementation with Q–EGCG was effective in augmenting GOBA and in countering inflammation after 3 d of heavy exertion in trained cyclists.

Additional Information

David C. Nieman, Dru A. Henson, Kendra R. Maxwell, Ashley S. Williams, Steven R. Mcanulty, Fuxia Jin, R. Andrew Shanely And Thomas C. Lines (2009). "Effects Of Quercetin And EGCG On Mitochondrial Biogenesis And Immunity." American College of Sports Medicine Version of Record Available At www.ncbi.nlm.nih.gov (DOI: 10.1249/MSS.0b013e318199491f)
Language: English
Date: 2009
Flavonoids, Cytokines, Granulocytes, Inflammation, Mitochondria

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