Quercetin Supplementation Does not alter Antioxidantstatus in Humans

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Dr.. David Nieman, Director (Creator)
Andrew Shanely Ph.D, Associate Professor (Creator)
Appalachian State University (ASU )
Web Site: https://library.appstate.edu/

Abstract: This study measured the influence of ingesting quercetin on plasma measures for oxidative stress and antioxidant capacity. Male and female subjects (n = 1002) varying in age (18–85 years) and body mass index (BMI) (16.7–52.7 kg/m2) were studied. Subjects were randomized to one of three groups using double-blinded methods: placebo, 500 mg or 1000 mg quer- cetin/day with 125 mg or 250 mg vitamin C/day, respectively. Pre- and post-study fasting bloodsamples show that plasma quercetin increased in a dose-responsive manner. The pattern of change in plasma F2-isoprostanes, oxidized low density lipoprotein, reduced glutathione, ferric reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) did not differ between supplementation groups or after adjustment for gender, age, BMI and disease status. In summary, quercetin supplementation over 12 weeks in doses of 500 mg or 1000 mg/day significantly increased plasma quercetin levels, but had no influence on several measures of oxidative stress and antioxidant capacity

Additional Information

R. ANDREW SHANELY, AMY M. KNAB, DAVID C. NIEMAN, FUXIA JIN, STEVEN R. MCANULTY, & MICHAEL J. LANDRAM (2010) "Quercetin Supplementation Does not alter Antioxidantstatus in Humans" Free Radical Research 44:224-231 Version of Record available @ (DOI: 10.3109/10715760903407293)
Language: English
Date: 2010
quercetin, FRAP, ORAC, f2-isoprostanes, LDL, gluathione, antioxidant, oxidative-stress,

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