Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Dr.. David Nieman, Director (Creator)
Andrew Shanely Ph.D, Associate Professor (Creator)
Appalachian State University (ASU )
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Abstract: This study investigated the influence of age, body composition, physical fitness, training volume and intensity, and underlying systemic inflammation on exercise-induced inflammation and innate immune function in a heterogeneousgroup of cyclists. Subjects included 31 male cyclists (mean – standard deviation, age 38.8 – 10.6 years, body fat 17.8% –5.6%, VO2max 55.8 – 8.4 mL kg - 1 min - 1) who cycled for 1.75 h at 60% wattsmax followed by a 10-km time trial (18.3– 0.3 min). Blood samples were collected pre-, post-, and 1-h-postexercise, and analyzed for WBCs, 9 cytokines[interleukin (IL)-6, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor, interferon-g, IL-1b,IL-2, IL-8, IL-10, and IL-12p70], and granulocyte and monocyte phagocytosis (GR-PHAG and MO-PHAG) and oxidative burst activity (GR-OBA and MO-OBA). Exercise- induced changes varied widely, with significant increasesmeasured for 8 of 9 cytokines, GR-PHAG (mean change 99%) (95% confidence limits, 69%, 128%) and MO-PHAG(43%) (28%, 58%), and WBC (160%) (133%,187%), and decreases for GR-OBA (- 30%) (- 43%, - 16%) and MO-OBA (-23%) (- 36%, -10%). Correlation and stepwise regression analysis revealed that changes in these variables were not related to age, body fat percentage, VO2max, training volume, or pre-exercise C-reactive protein. Performance measures, specifically the average heart rate and rating of perceived exertion, were correlated with changes in several variables, including IL-8 (r = 0.68 and 0.67, respectively, P < 0.001) and IL-6 (r = 0.51, P = 0.004, and r = 0.46, P = 0.011,respectively). In summary, variance in exercise-induced inflammation and innate immunity in male cyclists in responseto 2 h of endurance exercise is best explained by exercise intensity.

Additional Information

David C. Nieman, Manuela Konrad, Dru A. Henson, Krista Kennerly, R. Andrew Shanely, and Sandra J. Wallner Liebmann (2012) "Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity" Journal of Interferon & Cytokine Research 32:12-7 Version of Record Available @ (DOI: 10.1089/jir.2011.0038)
Language: English
Date: 2012
cycling, exercise-intensity, acute-inflammatory-response

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