Heterogeneity In Enterotoxigenic Escherichia coli And Shigella Infections In Children Under 5 Years Of Age From 11 African Countries: A Subnational Approach Quantifying Risk, Mortality, Morbidity, And Stunting

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Richard Rheingans Ph.D., Department Chair (Creator)
Appalachian State University (ASU )
Web Site: https://library.appstate.edu/

Abstract: Diarrhoea, a global cause of child mortality and morbidity, is linked to adverse consequences including childhood stunting and death from other diseases. Few studies explore how diarrhoeal mortality varies subnationally, especially by cause, which is important for targeting investments. Even fewer examine indirect effects of diarrhoeal morbidity on child mortality. We estimated the subnational distribution of mortality, morbidity, and childhood stunting attributable to enterotoxigenic Escherichia coli (ETEC) and shigella infection in children younger than 5 years from 11 eastern and central African countries. These pathogens are leading causes of diarrhoea in young children and have been linked to increased childhood stunting. We combined proxy indicators of morbidity and mortality risk from the most recent Demographic and Health Surveys with published relative risks to estimate the potential distribution of diarrhoeal disease risk. To estimate subnational burden, we used country-specific or WHO region-specific morbidity and mortality estimates and distributed them subnationally by three indices that integrate relevant individual characteristics (ie, underweight, probability of receiving oral rehydration treatment of diarrhoea, and receiving vitamin A supplementation) and household characteristics (ie, type of drinking water and sanitation facilities).

Additional Information

Bagamian KH, Anderson IJD, Muhib F, et al. Heterogeneity in enterotoxigenic Escherichia coli and shigella infections in children under 5 years of age from 11 African countries: a subnational approach quantifying risk, mortality, morbidity, and stunting. The Lancet Global Health. 2020;8(1):e101-e112. doi:10.1016/ S2214-109X(19)30456-5. Publisher version of record available at: https://www.sciencedirect.com/science/article/pii/S2214109X19304565?via%3Dihub
Language: English
Date: 2020
Escherichia coli (ETEC), shigella infection, Diarrhoea, health, mortality, morbidity, water, Africa, child mortality

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