Quercetin with Vitamin C and Niacin does not affect body Mass or Composition

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Dr.. David Nieman, Director (Creator)
Andrew Shanely Ph.D, Associate Professor (Creator)
Appalachian State University (ASU )
Web Site: https://library.appstate.edu/

Abstract: In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C andniacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male;18–85 years of age; 45%normal body mass index, 30% overweight, 25% obese). Subjects were randomized into 3groups, with supplements adminis-tered in double-blind fashion: Q500 = 500 mg quercetin·day–1, Q1000 = 1000 mg quercetin·day–1, and placebo. Quercetin supplements were consumed twice daily over a 12-week period, andpre- and poststudy body mass and composition meas-urements were taken in an overnight fasted state. A general linear model was used to predict change in body mass and com-position across groups with adjustment for demographic and lifestyle factors. Plasma quercetin increased in a dose-responsive manner in both Q500 and Q1000 groups relative to placebo. After adjustment for confounders, no significant dif-ferences in body mass (malesinteraction p value = 0.721, females p = 0.366) or body composition (males p = 0.650, fe-males p = 0.639) were found between Q500 or Q1000 groups compared with placebo. No group differences in body mass or body composition were found in a subgroup of overweight and obese subjects. High-dose quercetin supplementation (500 and 1000 mg·day–1) for 12 weeks in a large, heterogeneous group of adults did not affect body mass or composition.

Additional Information

Amy M. Knab, R. Andrew Shanely, Fuxia Jin, Melanie D. Austin, Wei Sha, and David C.Nieman (2011) "Quercetin with Vitamin C and Niacin does not affect body Mass or Composition" Applied Physiology, Nutrition, and Metabolism 36: pp. 331-338 Version of Record Available @ (DOI: 10.1139/h11-015)
Language: English
Date: 2011
quercetin, vitamin-C, niacin, body-mass, composition

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