Influence of Quercetin Supplementation on Disease Risk Factors in Community-Dwelling Adults

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Dr.. David Nieman, Director (Creator)
Andrew Shanely Ph.D, Associate Professor (Creator)
Appalachian State University (ASU )
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Abstract: Background: In vitro data indicate quercetin has anti-oxidative and anti-inflammatory functions with the potential to lower disease risk factors, but data in human beings are limited.Objective The objective of this study was to investigate the effect of quercetin, vitamin C, and niacin supplements (500 mg quercetin, 125 mg vitamin C, and 5 mg niacin [Q-500]; 1,000 mg quercetin, 250 mg vitamin C, and 10 mg niacin [Q-1,000]), on disease risk factors in a large group of community adults (n=1,002, 60% women) varying widely in age and body mass index. Design Subjects were randomized into one of three groups (placebo, Q-500, or Q-1,000) and ingested supplements for 12 weeks. Bloodsamples were taken pre- and post-supplementation, and plasma quercetin, inflammatory markers (ie, Creactiveprotein and five cytokines), diagnostic blood chemistries, blood pressure, and blood lipidprofiles were measured.Results Plasma quercetin increased in the Q-500 and Q-1,000 groups. No differences in bloodchemistries were found except for a small decrease in serum creatinine and increase in glomerular filtration rate in Q-500 and Q- 1,000 groups. A small decrease in mean arterial blood pressure wasmeasured for Q-500 and Q-1,000 groups compared to placebo. A difference in serum total cholesterol was measured between Q-500 and placebo groups, and there was small decrease in high-density lipoprotein cholesterol levels in the Q-1,000 group. Change in inflammatory measures did not differbetween groups except for a slight decrease in interleukin-6 for the Q-1,000 group. Conclusions Q-500or Q-1,000 supplementation for 12 weeks had a negligible influence on disease risk factors.

Additional Information

AMY M. KNAB; ANDREW SHANELY; DRU A. HENSON ; FUXIA JIN ; SERENA A. HEINZ; MELANIE D. AUSTIN ; DAVID C. NIEMAN ( 2011) "Influence of Quercetin Supplementation on Disease Risk Factors in Community-Dwelling Adults" Journal of American Diet Association. 111:542-549 Version of Record Available @ (doi: 10.1016/j.jada.2011.01.013)
Language: English
Date: 2011
quercetin, disease-risk-factors, community-dwelling, flavonoids

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