Combined fruit and vegetable intake are correlated with improved inflammatory and oxidant status from a crosssectional study in a community setting

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Dr.. David Nieman, Director (Creator)
Martin Root Ph.D, Associate Professor (Creator)
Andrew Shanely Ph.D, Associate Professor (Creator)
Appalachian State University (ASU )
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Abstract: Previous studies have examined the relationship between specific nutrient and food intakes with limited markers of either inflammation or oxidant status. The objective of this study was to determine if an increase in combined selfreported fruit and vegetable (F&V) intake in a community setting was associated with improved multiple markers of inflammatory and oxidant status. A community group (N = 1000, age 18–85 years, 61% female) gave two fasted blood samples separated by 12 weeks. Blood inflammatory biomarkers included total leukocytes (WBC), plasma C-reactiveprotein (CRP), interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-a), monocyte chemoattractant protein-1, and granulocyte colony stimulating factor. Measured oxidant status markers were ferric reducing ability of plasma (FRAP), oxygen radical absorbance capacity (ORAC) and plasma F2-isoprostanes. The relation of markers across categories of F&V intake was examined. In analyses controlling for other important dietary and lifestyle factors, IL-6 and TNF-a were significantly lower across categories of increasing F&V intakes (p < 0.008). FRAP and ORAC weresignificantly higher (p < 0.0001 and p = 0.047 respectively) while F2-isoprostanes was significantly lower (p < 0.0001)across F&V categories. In a community study, several markers of both inflammation and oxidant status were associatedin a putatively salutary direction by higher intake of combined F&V, supporting current guidelines suggesting increased F&V consumption for the prevention of chronic diseases.

Additional Information

Root MM, McGinn MM, Nieman DC, Henson DA, Heinz SA, Shanely RA, Knab, AM, Jin F. (2012) "Combined fruit and vegetable intake are correlated with improved inflammatory and oxidant status from a cross-sectional study in a community setting" Nutrients 4: pp.29-41 Version of Record available @ (doi:10.3390/nu4010029)
Language: English
Date: 2012
fruits, vegetables, inflammation, oxidant-status

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