Dr. David Nieman

David Nieman is a professor in the College of Health Sciences at Appalachian State University, and director of the Human Performance Lab at the North Carolina Research Campus (NCRC) in Kannapolis, NC (www.ncresearchcampus.net). Dr. Nieman is a pioneer in the research area of exercise immunology, and helped establish that 1) regular moderate exercise lowers upper respiratory tract infection rates while improving immunosurveillance, 2) heavy exertion increases infection rates while causing transient changes in immune function, and 3) that carbohydrate and flavonoid ingestion by athletes attenuates exercise-induced immune dysfunction.

There are 33 included publications by Dr. David Nieman :

TitleDateViewsBrief Description
A 45-Minute Vigorous Exercise Bout Increases Metabolic Rate For 14 Hours 2011 333 Introduction: The magnitude and duration of the elevation in resting energy expenditure after vigorous exercise have not been measured in a metabolic chamber. This study investigated the effects of inserting a 45-min vigorous cycling bout into the da...
Bananas as an Energy Source during Exercise: A Metabolomics Approach 2016 568 This study compared the acute effect of ingesting bananas (BAN) versus a 6% carbohydrate drink (CHO) on 75-km cycling performance and post-exercise inflammation, oxidative stress, and innate immune function using traditional and metabolomics-based pr...
Carbohydrate Ingestion Influences Skeletal Muscle Cytokine mRNA And Plasma Cytokine Levels After A 3 Hour Run 2003 4 Sixteen experienced marathoners ran on treadmills for 3 h at ~ 70% maximal oxygen consumption (Vo2 max) on two occasions while receiving 1 l/h carbohydrate (CHO) or placebo (Pla) beverages. Blood and vastus lateralis muscle biopsy samples were collec...
Combined fruit and vegetable intake are correlated with improved inflammatory and oxidant status from a crosssectional study in a community setting 2012 285 Previous studies have examined the relationship between specific nutrient and food intakes with limited markers of either inflammation or oxidant status. The objective of this study was to determine if an increase in combined selfreported fruit and v...
A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial 2013 655 Background-The purpose of this study was to assess the effect of 8-weeks ingestion of a commercialized joint pain dietarysupplement (InstaflexTM Joint Support, Direct Digital, Charlotte, NC) compared to placebo on joint pain, stiffness, and function ...
Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity 2016 740 Consuming carbohydrate- and antioxidant-rich fruits during exercise as a means of supporting and enhancing both performance and health is of interest to endurance athletes. Watermelon (WM) contains carbohydrate, lycopene, L-citrulline, and L-arginine...
Effect Of Mixed Flavonoids, N-3 Fatty Acids, And Vitamin C On Oxidative Stress And Antioxidant Capacity Before And After Intense Cycling 2011 10 Consumption of plant flavonoids, antioxidants, and n-3 fatty acids is proposed to have many potential health benefits derived primarily through antioxidant and anti-inflammatory activities. This study examined the effects of 1,000 mg quercetin + 1,00...
Effect Of N-3 Fatty Acids And Antioxidants On Oxidative Stress After Exercise 2010 5 Purpose: n-3 fatty acids are known to exert multiple beneficial effects including anti-inflammatory actions that may diminish oxidative stress. Supplementation with antioxidant vitamins has been proposed to counteract oxidative stress and improve ant...
Effects of a Flavonoid-Rich Juice on Inflammation, Oxidative Stress, and Immunity in Elite Swimmers: A Metabolomics-Based Approach 2013 982 The effects of a flavonoid-rich fresh fruit and vegetable juice (JUICE) on chronic resting and postexercise inflammation, oxidative stress, immune function, and metabolic profiles (metabolomics analysis, gas-chro-matography mass-spectrometry platform...
Effects of a freeze-dried juice blend powder on exercise induced inflammation, oxidative stress, and immune function in cyclists 2014 559 A freeze-dried fruit and vegetable juice powder (JUICE) was investigated as a countermeasure nutritional strategy to exercise-induced inflammation, oxidative stress, and immune perturbations in trained cyclists. Thirty-fourcyclists (25 male, 9 female...
Effects Of Quercetin And EGCG On Mitochondrial Biogenesis And Immunity 2009 782 Purpose: To test the influence of 1000 mg of quercetin (Q) with or without 120 mg of epigallocatechin 3-gallate (EGCG), 400 mg of isoquercetin, and 400 mg of eicosapentaenoic acid and docosahexaenoic acid (Q–EGCG) on exercise performance, muscle mito...
IL-6 Linkage To Exercise-Induced Shifts In Lipid-Related Metabolites: A Metabolomics-Based Analysis 2017 270 Metabolomics profiling and bioinformatics technologies were Substantial increase In used to determine the relationship between exercise-induced increases in IL-6 and lipid-related metabolites 6 and lipid-related metabolites. Twenty-four male runners ...
Immune And Inflammation Responses To A 3-Day Period Of Intensified Running Versus Cycling 2016 978 Functional overreaching has been linked to alterations in immunity and host pathogen defense, but little is known as to whether or not running and cycling evoke different responses. This study compared inflammation, muscle damage and soreness, and in...
Immune And Oxidative Changes During And Following The Western States Endurance Run 2003 7 Changes in immune and oxidative stress parameters were measured in ultramarathon runners competing in the 160-km Western States Endurance Run. Forty-five runners agreed to provide blood and saliva samples the morning before the race event, at the 90-...
Inflammation And Oxidative Stress Are Lower In Physically fit And Active Adults 2011 408 The objective of this study was to determine if the inverse relationship between perceived physical fitness (pFIT) and exercise frequency (ExFreq) levels and chronic inflammation and oxidative stress exists after making statistical adjustments for co...
Influence Of Carbohydrate Ingestion On Oxidative Stress And Plasma Antioxidant Potential Following A 3 Hour Run 2004 11 Concentrations of reactive oxygen species (ROS) increase during exercise secondary to increased oxygen uptake, xanthine oxidase activity, and immune system activation. Carbohydrate compared to placebo beverage ingestion is associated with an attenuat...
Influence Of Pistachios On Performance And Exercise-Induced Inflammation, Oxidative Stress, Immune Dysfunction, And Metabolite Shifts In Cyclists: A Randomized, Crossover Trial 2014 350 Objectives: Pistachio nut ingestion (3 oz./d, two weeks) was tested for effects on exercise performance and 21-h post-exercise recovery from inflammation, oxidative stress, immune dysfunction, and metabolite shifts. Methods: Using a randomized, cross...
Influence of Quercetin Supplementation on Disease Risk Factors in Community-Dwelling Adults 2011 751 Background: In vitro data indicate quercetin has anti-oxidative and anti-inflammatory functions with the potential to lower disease risk factors, but data in human beings are limited.Objective The objective of this study was to investigate the effect...
Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach 2012 1015 Red pepper spice (RP) and turmeric (TM) are used as flavorings in foods and for medicinalpurposes. Utilizing a randomized, doubled-blinded, placebo-controlled, crossover design (2-week washout), 4-week supplementation with RP (1 g/d) or TM (2.8 g/d) ...
Influence Of Vitamin C Supplementation On Oxidative And Immune Changes After An Ultramarathon 2002 5 The purpose of this randomized study was to measure the influence of vitamin C (n = 15 runners) compared with placebo (n = 13 runners) supplementation on oxidative and immune changes in runners competing in an ultramarathon race. During the 7-day per...
Influence Of Vitamin C Supplementation On Oxidative And Salivary IgA Changes Following An Ultramarathon 2003 2 This randomized study measured the influence of vitamin C (N=15) compared to placebo (N=13) supplementation on oxidative and salivary immunoglobulin A (sIgA) changes in runners competing in an ultramarathon race. Seven days prior to the race, subject...
Infuence Of 2-Weeks Ingestion Of High Chlorogenic Acid Coffee On Mood State, Performance, And Postexercise Inflammation And Oxidative Stress: A Randomized, Placebo-Controlled Trial 2018 116 This study measured the influence of 2-weeks ingestion of high chlorogenic acid (CQA) coffee on postexercise inflammation and oxidative stress, with secondary outcomes including performance and mood state. Cyclists (N = 15) were randomized to CQA cof...
Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling 2014 687 Bioactive oxidized linoleic acid metabolites (OXLAMs) include 13- and 9-hydroxy-octadecadienoic acid (13-HODE + 9-HODE) and have been linked to oxidative stress, in?ammation, and numerous pathological and physiological states. The purpose of this stu...
n-3 Polyunsaturated Fatty Acids Do Not Alter Immune And Inflammation Measures In Endurance Athletes 2009 9 The purpose of this study was to test the influence of 2.4 g/d fish oil n-3 polyunsaturated fatty acids (n-3 PUFA) over 6 wk on exercise performance, inflammation, and immune measures in 23 trained cyclists before and after a 3-d period of intense ex...
Perceived Stress and ADHD Symptoms in Adults 2015 640 Given that ADHD has been linked to dysfunction across development and in many life domains, it is likely that individuals experiencing these symptoms are at increased risk for experiencing stress. The current study examines the association between AD...
The Protective Effects of a Polyphenol-Enriched Protein Powder on Exercise-Induced Susceptibility to Virus Infection 2014 631 Prolonged and intensive exercise induces transient immunosuppression and is associated with an increased risk and severity of infections. The goal of this study was to characterize the antiviral and antibacterial properties of the bioactive metabolit...
Quercetin Supplementation Does not alter Antioxidantstatus in Humans 2010 734 This study measured the influence of ingesting quercetin on plasma measures for oxidative stress and antioxidant capacity. Male and female subjects (n = 1002) varying in age (18–85 years) and body mass index (BMI) (16.7–52.7 kg/m2) were studied. Subj...
Quercetin with Vitamin C and Niacin does not affect body Mass or Composition 2011 633 In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 1...
Quercetin's Influence On Exercise Performance And Muscle Mitochondrial Biogenesis 2010 1132 Purpose: To determine the influence of 2 wk of quercetin (Q; 1000 mg·d-1) compared with placebo (P) supplementation on exercise performance and skeletal muscle mitochondrial biogenesis in untrained, young adult males (N = 26, age = 20.2 ± 0.4 yr, V·...
Ratings Of Perceived Exertion Throughout An Ultramarathon During Carbohydrate Ingestion 2003 3 Ratings of perceived exertion (RPE) and their relation to selected physiological mediators during endurance exercise have been limited to laboratory settings. The present study characterized the pattern of change in perceptual responses and examined ...
Rhodiola rosea exerts antiviral activity in athletes following a competitive marathon race 2015 792 Rhodiola rosea, a medicinal plant with demonstrated adaptogenic properties, has recently been reported to contain active compounds with antimicrobial activity. The goal of this study was to measure the antiviral and antibacterial properties of the bi...
The variable plasma quercetin response to 12-week quercetin supplementation in humans 2010 656 Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and l...
Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity 2012 723 This study investigated the influence of age, body composition, physical fitness, training volume and intensity, and underlying systemic inflammation on exercise-induced inflammation and innate immune function in a heterogeneousgroup of cyclists. Sub...