Metabolomics
- UNCW Author/Contributor (non-UNCW co-authors, if there are any, appear on document)
- Teresa Emilea Norris (Creator)
- Institution
- The University of North Carolina Wilmington (UNCW )
- Web Site: http://library.uncw.edu/
- Advisor
- Susan Simmons
Abstract: Metabolomics is the newest of the “-omics” sciences showing great potential in
identifying biomarkers for drug discovery. Since Metabolomics is a relatively new science there
are a few issues that have not been investigated to a great extent. As advances in this area are
being made, there is a need for better analysis methods that provide adequate and trustworthy
results.
Presented in this research are the issues that cloud the great potential for analyzing a
metabolomics data set. One of the biggest issues comes from the missing values of metabolite
concentrations due to an assay threshold. Different imputation methods are evaluated, and how
these affect feature selection with respect to a disease status.
The goal is to provide more research in these areas through exploration of imputation and
feature selection methods. Once conclusions are made, there will be a pathway to help further
metabolomics research.
Metabolomics
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Created on 1/1/2009
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Additional Information
- Publication
- Thesis
- A Thesis Submitted to the University of North Carolina at Wilmington in Partial Fulfillment of the Requirement for the Degree of Masters of Science
- Language: English
- Date: 2009
- Keywords
- Biological systems, Metabolic profile tests, Metabolites--Analysis, Metabolites--Mathematical models
- Subjects
- Metabolic profile tests
- Metabolites -- Analysis
- Metabolites -- Mathematical models
- Biological systems