|Design and synthesis of DNA minor groove methylating compounds that target pancreatic 7-cells
||The design of compounds that form cytotoxic, non-mutagenic 3-methyladenine adducts
in pancreatic ß-cells is being studied in this project for potential applications in the treatment of
diseases such as diabetes and cancer. These compounds are compo...
|Synthesis of compounds capable of producing cytotoxic N3-methyladenine DNA adducts in estrogen receptor positive cells
||This project describes the design and synthesis of new compounds that are capable of
targeting cells that express the estrogen receptor and producing cytotoxic N3-methyladenine
DNA adducts in those cells. These compounds contain a reactive methylsu...
|Modulation of lipid domain formation in mixed model systems by proteins and peptides
||The control of lipid domain formation in biological membranes has received limited consideration. This mechanism is quantitatively investigated using Monte Carlo computer simulations of a simple model system. Monte Carlo simulations are performed on ...
|Synthesis of site specific DNA methylating compounds targeting pancreatic ß-cells
||This project involves synthesizing compounds that are capable of producing cytotoxic N3-methyladenine DNA adducts in pancreatic ß-cells. The compounds will consist of three units: 1) A cell targeting ligand, glucose, which is specific to the insulin ...