Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
- UNCP Author/Contributor (non-UNCP co-authors, if there are any, appear on document)
- Dr . Ben Bahr, William C. Friday Chair and Professor of Molecular Biology and Biochemistry (Creator)
- Institution
- The University of North Carolina at Pembroke (UNCP )
- Web Site: http://www.uncp.edu/academics/library
Abstract: Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). Mutations of these genes lead to dysfunction in multiple steps of the endo-lysosomal network: autophagy, endocytic trafficking and lysosomal degradation, resulting in accumulation of pathogenic proteins. Although the exact pathogenic mechanism varies for different disease-associated genes, dysfunction of the endo-lysosomal pathways represents a converging mechanism shared by these diseases. Therefore, strategies that correct or compensate for endo-lysosomal dysfunction may be promising therapeutic approaches to treat neurodegenerative diseases.
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
PDF (Portable Document Format)
747 KB
Created on 4/2/2018
Views: 1209
Additional Information
- Publication
- Current opinion in neurobiology, Vol. 48
- Language: English
- Date: 2017
- Keywords
- endo-lysosomal, autophagy, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, endocytical trafficking