Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Jianjun Wei, Associate Professor (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: Near-infrared emissive BODIPY polymeric dye bearing cancer-homing cyclic arginine–glycine–aspartic acid (RGD) peptide residues (polymer B) was prepared by post-polymerization functionalization of BODIPY polymeric dye bearing bromo groups through tetra(ethylene glycol) tethered spacers (polymer A) with thiol-functionalized RGD cancer-homing peptide through thioether bonds under a mild basic condition. Polymer B possesses excellent water solubility, good photostability, biocompatibility and resistance to nonspecific interactions to normal endothelial cells, and can efficiently detect breast tumor cells through specific cooperative binding of cancer-homing RGD peptides to avß3 integrins of cancer cells while its parent polymer A without RGD residues fails to target cancer cells.

Additional Information

Publication
Analytica Chimica Acta, 2013, 758, 138–144.
Language: English
Date: 2013
Keywords
BODIPY dye, Conjugated polymer, Cancer imaging, Fluorescence, RGD peptide

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