|A screen for modifiers of teflon identifies novel components of the meiotic segregation pathway in male Drosophila melanogaster
||The teflon (tef) gene is required specifically for ensuring adhesion between autosomes in male meiosis. In tef mutants, autosomal homologs pair correctly, but separate prior to metaphase, resulting in random segregation of homologs at meiosis I. To i...
|Identification of dTopors domains required for subcellular localization
||The Topors protein is a tumor suppressor in humans that associates with and regulates a number of cell cycle regulators that include Topoisomerase I and p53. It possesses both ubiquitin and SUMO ligase activity and its mutation or downregulation has ...
|Regulation of sumoylation by dTopors during male meiosis in Drosophila melanogaster
||The Topors protein is a tumor suppressor in human that associates with and regulates a number of cell cycle regulators that including topoisomerase I and p53. It possesses both ubiquitin and SUMO ligase activity and its mutation or downregulation has...
|Identifying the binding sequence of Teflon, a protein required for autosomal homolog conjunction during meiosis I in Drosophila melanogaster males
||Teflon (Tef) is a gene required for paired autosomes to maintain connections until Anaphase I in male Drosophila melanogaster. The protein contains three canonical zinc finger motifs, which are typically involved in sequence-specific DNA binding, sug...
|Effects of dtopors on soma and germ line aging in male Drosophila
||Nuclei are given support and structure by a network of proteins and filaments called the nuclear lamina. Mutations in many genes encoding lamina components result in human diseases known as the laminopathies. Hutchinson-Gilford Progeria Syndrome (HGP...